rs759834365, BDNF-AS;BDNF

N. diseases: 237
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132 2020
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132 2020
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE Thus, we assessed whether the functional single nucleotide polymorphism (SNP) on the BDNF gene, Val66Met, moderated the relationship between depressive symptoms and perceived social support and unsupportive relationships, and whether these associations differed by gender. 31364951 2020
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly. 31771052 2020
Mental Depression
CUI: C0011570
Disease: Mental Depression
0.100 GeneticVariation BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132 2020
Nonorganic psychosis
CUI: C0349204
Disease: Nonorganic psychosis
0.100 GeneticVariation BEFREE The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum. 29785763 2019
Obsessive-Compulsive Disorder
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
0.100 GeneticVariation BEFREE Findings from this meta-analytic investigation of published literature provide little support for the Val66Met variant of BDNF as a predictor of OCD. 31291217 2019
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome. 31822818 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism. 30659208 2019
Anxiety
CUI: C0003467
Disease: Anxiety
0.100 GeneticVariation BEFREE The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder. 30269521 2019
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694 2019
Abnormal behavior
CUI: C0233514
Disease: Abnormal behavior
0.100 GeneticVariation BEFREE In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice. 30992540 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers. 30775992 2019
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.100 GeneticVariation BEFREE Few genetic studies exploring the impact of Val66Met on cognition in BD. 30078664 2019
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE Fifty-two samples from the depressed patient group were genotyped for the Val66Met BDNF polymorphism. 29802070 2019
Depressed mood
CUI: C0344315
Disease: Depressed mood
0.100 GeneticVariation BEFREE The BDNF Val66Met contributed to the severity of CSI even after adjusting to PTSD, depression and LEC. 30904785 2019
Depressive Symptoms
CUI: C0086132
Disease: Depressive Symptoms
0.100 GeneticVariation BEFREE The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. 31197095 2019
Depressive disorder
CUI: C0011581
Disease: Depressive disorder
0.100 GeneticVariation BEFREE The Val66Met polymorphism did not appear to predict BDNF levels, depression incidence, or modify the relationship between dietary quality and BDNF. 29280414 2019
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169 2019
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.100 GeneticVariation BEFREE The relationship was investigated between brain-derived neurotrophic factor (BDNF) concentrations, a <i>BDNF</i> polymorphism (196G>A), and the response to selective serotonin reuptake inhibitors (SSRIs) among Chinese patients with major depressive disorder (MDD). 31308724 2019
Obsessive-Compulsive Disorder
CUI: C0028768
Disease: Obsessive-Compulsive Disorder
0.100 GeneticVariation BEFREE Regression analysis determined the extent to which psychiatric comorbidity, illness severity, OCD symptom dimensions, childhood trauma history, and the Val66Met (rs6265) polymorphism of the brainderived neurotrophic factor (BDNF) gene predict lifetime suicidal ideation and attempts in adults with OCD. 31046037 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy. 30382534 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169 2019
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.100 GeneticVariation BEFREE The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum. 29785763 2019
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.100 GeneticVariation BEFREE We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE. 29952080 2019