Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Malignant neoplasm of pancreas
|
0.020 | GeneticVariation | BEFREE | Spontaneous mouse model of PC (K-ras(G12D); Pdx-1cre) showed early expression of Ncoa3 during pre-neoplastic lesions. | 25531332 | 2015 | |||||
Pancreatic carcinoma
|
0.020 | GeneticVariation | BEFREE | Spontaneous mouse model of PC (K-ras(G12D); Pdx-1cre) showed early expression of Ncoa3 during pre-neoplastic lesions. | 25531332 | 2015 | |||||
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 | GeneticVariation | BEFREE | We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC. | 22945649 | 2013 | |||||
Malignant neoplasm of pancreas
|
0.020 | GeneticVariation | BEFREE | In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR. | 23102107 | 2012 | |||||
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.020 | GeneticVariation | BEFREE | In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR. | 23102107 | 2012 | |||||
Pancreatic carcinoma
|
0.020 | GeneticVariation | BEFREE | In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR. | 23102107 | 2012 | |||||
Pancreatic intraepithelial neoplasia
|
0.010 | GeneticVariation | BEFREE | In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR. | 23102107 | 2012 | |||||
Pancreatic Ductal Adenocarcinoma
|
0.010 | GeneticVariation | BEFREE | In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR. | 23102107 | 2012 | |||||
Endometriosis
|
0.010 | GeneticVariation | BEFREE | To test our hypothesis, we crossed MUC1 transgenic mice, which express human MUC1 under the endogenous promoter, with the loxP-Stop-loxP-Kras(G12D/+) (Kras) mice, in which endometriosis can be induced through Cre-loxP recombination. | 19841240 | 2010 | |||||
Papillary neoplasm
|
0.010 | GeneticVariation | BEFREE | Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. | 17785207 | 2007 | |||||
Secondary malignant neoplasm of pancreas
|
0.010 | GeneticVariation | BEFREE | We show that concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN). | 17785207 | 2007 |