Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2.
|
31691451 |
2020 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of rs7903146 polymorphism and adropin serum level in patients with diabetes mellitus; a case-control study from Isfahan, Iran.
|
31818149 |
2019 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped rs7903146 in 608 individuals without diabetes and recorded biochemical data before and after <i>1</i>) one dose of glipizide (5 mg) on visit 1 and <i>2</i>) a 75-g oral glucose tolerance test (OGTT) performed after administration of metformin 500 mg twice daily over 2 days.
|
29326107 |
2018 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.
|
30419301 |
2018 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied 120 individuals of whom one-half were homozygous for the diabetes-associated allele TT at rs7903146 and one-half were homozygous for the protective allele CC.
|
26525881 |
2016 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes.
|
27998387 |
2016 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study revealed no differences in the kinetics of glucose, insulin, C-peptide and non-esterified fatty acids during an OGTT in homozygous participants from a German diabetes risk cohort (n = 1832) carrying either the rs7903146 CC (n = 15) or the TT (n = 15) genotype.
|
24925104 |
2014 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%.
|
25058603 |
2014 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We hypothesised that both a parental history of diabetes and TCF7L2 rs7903146 polymorphism, which increases susceptibility to diabetes because of impaired beta cell function, are associated with incident hypertension.
|
23942764 |
2013 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P<0.001), higher baseline proinsulin:insulin ratio (p<0.0001) and increased proinsulin:insulin ratio over a median of 2.5 years of follow-up (P = 0.003).
|
21814547 |
2011 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant.
|
20980453 |
2011 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done.
|
21441683 |
2011 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recruited 189 patients with T2D being treated with SUs and determined the rs7903146 diabetes risk genotype.
|
21349175 |
2011 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years.
|
20578204 |
2010 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes.
|
20839289 |
2010 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over an average follow-up period of 5.43 years, participants with the rs7903146 T allele or variants in the same LD block, but not those with the rs290481 G allele, were more likely to progress to diabetes (hazard ratio = 2.61, 95% confidence interval, 1.27-5.39, P = 0.009) than were non-carriers.
|
19806338 |
2010 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes.
|
18931037 |
2009 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs7903146 T allele is associated with diabetes and, in non-diabetic individuals, with a higher prevalence and severity of coronary artery disease and cardiovascular events. name of registry site (see list below), registration number, trial registration URL in brackets.
|
19924244 |
2009 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with diabetes in CF in the family study (p = 0.004) and in the case-control study (p = 0.02; combined p = 0.0002).
|
19585101 |
2009 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for traditional diabetes risk factors (diabetes in family, waist circumference, physical activity, BMI, SBP and total and HDL-cholesterol) in both a cross-sectional and prospective setting (cross-sectional: rs12255372 OR 1.61 (1.31-1.99), rs7903146 OR 1.48 (1.20-1.83) and prospective: rs12255372 OR 1.59 (1.22-2.07), rs7903146 OR 1.47 (1.11-1.93)).
|
18972257 |
2009 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TCF7L2 rs7903146 T-allele was associated with type 2 diabetes (hazard ratio=1.51</span>; 95 % CI 1.21, 1.87) and modified the inverse association between whole-grain intake and diabetes risk (P=0.016 for interaction).
|
19149908 |
2009 |