Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hyperglycemia
CUI: C0020456
Disease: Hyperglycemia
0.050 GeneticVariation BEFREE Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02). 22461567 2012
Hyperglycemia
CUI: C0020456
Disease: Hyperglycemia
0.050 GeneticVariation BEFREE The T-allele of TCF7L2 rs7903146 polymorphism was independently associated with increasing fasting glucose values toward hyperglycemia in the follow-up. 20299486 2010
Hyperglycemia
CUI: C0020456
Disease: Hyperglycemia
0.050 GeneticVariation BEFREE Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). 18853134 2009
Hyperglycemia
CUI: C0020456
Disease: Hyperglycemia
0.050 GeneticVariation BEFREE We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia and a higher proinsulin/insulin ratio. 19183934 2009
Hyperglycemia
CUI: C0020456
Disease: Hyperglycemia
0.050 GeneticVariation BEFREE We conclude that the TCF7L2 T at-risk allele variation (rs7903146) predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion. 17065361 2007