|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
To assess if COPD-associated variants in 15q25.1 are methylation quantitative trait loci, epigenome-wide association analysis of four genetic variants, previously associated with COPD (P < 5 × 10<sup>-8</sup>) in the 15q25.1 locus (rs12914385:C>T-CHRNA3, rs8034191:T>C-HYKK, rs13180:C>T-IREB2 and rs8042238:C>T-IREB2), was performed in the Rotterdam study (n = 1489).
|
29422661 |
2018 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968, and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives.
|
27323020 |
2016 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Significant associations between the 4 SNPs and COPD were identified under allele (rs1051730: OR = 1.14, 95%CI = 1.10-1.18; rs8034191: OR = 1.29, 95%CI = 1.18-1.41; rs6495309: OR = 1.26, 95%CI = 1.09-1.45; rs16969968: OR = 1.27, 95%CI = 1.17-1.39) and genotype models.
|
25051068 |
2014 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
Our analysis revealed that effects of two linked variants (rs1051730 and rs8034191) in the AGPHD1/CHRNA3 cluster on COPD development are significantly, yet not entirely, mediated by the smoking-related phenotypes.
|
23299987 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
In the LEUVEN cohort, rs1051730 AA-carriers and rs8034191 GG-carriers had a two-fold increased risk to suffer from COPD GOLD IV (OR 2.29, 95% confidence interval [CI] = 1.11-4.75; p = 0.025 and OR = 2.42, 95% [CI] = 1.18-4.95; p = 0.016, respectively).
|
23349703 |
2013 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The SNP rs8034191 near CHRNA3/5 locus was significantly associated with pack-years of smoking in COPD patients (P=0.033).
|
22914670 |
2012 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).
|
22461431 |
2012 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
|
21921092 |
2011 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASCAT |
The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.
|
19300482 |
2009 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
BEFREE |
The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.
|
19300482 |
2009 |
|
Chronic Obstructive Airway Disease
|
|
0.880 |
GeneticVariation
|
GWASDB |
The C allele of the rs8034191 SNP was estimated to have a population attributable risk for COPD of 12.2%.
|
19300482 |
2009 |