|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
After dividing the HBV-infected individuals into patients in acute infection, chronic HBV patients, and patients undergoing convalescence, the genotype GT (<i>P</i> = 0.033) and allele G (<i>P</i> = 0.038) of rs8099917 showed statistically higher frequency in the acutely infectious individuals than in the HBV patients undergoing convalescence.
|
29302390 |
2017 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
There is no association between rs8099917 and HBV infection in Chinese population and Asian population.
|
25962810 |
2015 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
Logistic regression revealed that the strongest factors associated with spontaneous HCV seroclearance were carriage of rs8099917 TT-type (odds ratio/95% confidence intervals [OR/CI]: 6.22/1.41-27.35, p=0.016), followed by concurrent hepatitis B surface antigen (HBsAg) seropositivity (OR/CI: 2.37/1.06-5.26, p=0.035).
|
24096049 |
2014 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
Moreover, we found that IL28B rs8099917 G variants (TG+GG) interact with HCV genotype 1(G1) to result in higher risk of NVR (P=0.009), and that they are also associated with HBV DNA reactivation (TG+GG vs. TT, P=0.005).
|
24147097 |
2013 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
When adjusting for age, gender, smoking, drinking, and levels of hepatitis B virus (HBV) DNA, alanine aminotransferase, and HBV genotype, the rs8099917 genotype GT (OR, 4.025 [95% CI, 1.316-12.354; p = 0.013] and fibrosis stage (OR, 0.716 [95% CI, 0.432-0.986; p = 0.036] appeared to be associated with a higher probability of response to lamivudine treatment.
|
23586360 |
2013 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
To evaluate the role of host IL28B (interleukin 28B; interferon lambda 3) single nucleotide polymorphisms (SNPs) in predicting hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) susceptibility, three SNPs in the IL28B gene (rs12979860C/T, rs8099917G/T and rs12980275G/A) were examined in 330 subjects (including 154 HBV-related HCC patients, 86 non-HCC patients with chronic hepatitis B (CHB), 43 HBV self-limited infections and 47 healthy controls).
|
22310928 |
2012 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
The allele G of rs8099917 was associated with hepatitis B-related hepatocytes injury.
|
22325058 |
2012 |
|
Hepatitis B
|
|
0.080 |
GeneticVariation
|
BEFREE |
We determined three IL28B single gene polymorphisms (rs12979860, rs12980275 and rs8099917) in 203 individuals with chronic HBV infection, 203 individuals with self-limited HBV infection and 203 individuals negative for all HBV seromarkers.
|
21745278 |
2011 |