|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Additionally, both omentin Val109Asp and FTO rs9939609 polymorphisms were significantly positively correlated to familial history of diabetes (P = 0.046 and P = 0.024, respectively).
|
31200723 |
2019 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506).
|
28585683 |
2017 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
RESULTS Genotype distributions of rs10811661 (CDKN2A/2B), rs7195539, rs8050136, and rs9939609 (FTO) and allele frequencies of rs8050136 and rs9939609 differed significantly between diabetes and control groups (all P<0.05).
|
26873362 |
2016 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
This was a cross-sectional study of 236 patients with type 2 diabetes (age 60.0 ± 10.3 years; diabetes duration 12.7 ± 8.2 years; 53.4% females) who were genotyped for FTO rs9939609.
|
23689376 |
2013 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene, especially the common rs9939609 (A/T) SNP, are associated with body mass index (BMI), diabetes, and metabolic syndrome (MetS).
|
21741858 |
2012 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs9939609 polymorphism in the FTO gene is related to abnormal glucose levels and with LAP, a surrogate marker of diabetes and cardiovascular risk in postmenopause.
|
21868005 |
2011 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up.
|
21179003 |
2011 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining its relationship with diabetes.
|
21294771 |
2011 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
For white participants, the FTO rs9939609 A allele was associated with an increased risk of diabetes (odds ratio (OR) = 1.19, p<0.001) and obesity (OR = 1.22, p<0.001) under an additive genetic model that was similar for all of the SNPs analyzed.
|
20502638 |
2010 |
|
Diabetes Mellitus
|
|
0.800 |
GeneticVariation
|
BEFREE |
These results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, P = 1.3 x 10(-3); rs9939609, P = 9.8 x 10(-4); for obesity, rs8050136, P = 2.2 x 10(-7); rs9939609, P = 9.0 x 10(-9)).
|
20057365 |
2010 |