HOMOCYSTINURIA DUE TO DEFICIENCY OF N(5,10)-METHYLENETETRAHYDROFOLATE REDUCTASE ACTIVITY
|
disease |
|
Disease or Syndrome
|
5
|
78
|
0.800 |
definitive |
1.000 |
35 |
78
|
1991 |
2019 |
Methylenetetrahydrofolate reductase deficiency
|
disease |
Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
|
Disease or Syndrome
|
5
|
4
|
0.700 |
definitive |
1.000 |
18 |
4
|
1991 |
2019 |
Depressive disorder
|
disease |
Mental Disorders
|
Mental or Behavioral Dysfunction
|
1719
|
297
|
0.600 |
None |
1.000 |
33 |
3
|
1997 |
2019 |
Unipolar Depression
|
disease |
Mental Disorders
|
Mental or Behavioral Dysfunction
|
641
|
225
|
0.600 |
None |
1.000 |
13 |
3
|
1997 |
2020 |
Bipolar Disorder
|
disease |
Mental Disorders
|
Mental or Behavioral Dysfunction
|
1183
|
839
|
0.600 |
None |
1.000 |
13 |
5
|
2006 |
2015 |
Coronary heart disease
|
disease |
Cardiovascular Diseases
|
Disease or Syndrome
|
1576
|
1178
|
0.500 |
None |
0.912 |
114 |
9
|
1991 |
2019 |
Cerebrovascular accident
|
group |
Nervous System Diseases; Cardiovascular Diseases
|
Disease or Syndrome
|
1658
|
591
|
0.500 |
None |
0.938 |
97 |
4
|
1997 |
2019 |
Schizophrenia
|
disease |
Mental Disorders
|
Mental or Behavioral Dysfunction
|
2872
|
2897
|
0.500 |
None |
0.859 |
64 |
8
|
1997 |
2019 |
Deep Vein Thrombosis
|
disease |
Cardiovascular Diseases
|
Disease or Syndrome
|
230
|
93
|
0.500 |
None |
0.931 |
29 |
6
|
1997 |
2020 |
Spina Bifida
|
disease |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
|
Congenital Abnormality
|
179
|
61
|
0.500 |
None |
0.962 |
26 |
4
|
1995 |
2017 |
Neural tube defect, folate-sensitive
|
disease |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
|
Disease or Syndrome
|
8
|
2
|
0.500 |
None |
1.000 |
1 |
|
2001 |
2001 |
Meningomyelocele
|
disease |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
|
Congenital Abnormality
|
89
|
27
|
0.470 |
None |
1.000 |
8 |
5
|
1999 |
2015 |
Anencephaly
|
disease |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
|
Congenital Abnormality
|
59
|
10
|
0.440 |
None |
1.000 |
5 |
2
|
1996 |
2015 |
Seizures
|
phenotype |
Pathological Conditions, Signs and Symptoms; Nervous System Diseases
|
Sign or Symptom
|
2152
|
553
|
0.440 |
strong |
1.000 |
5 |
2
|
1998 |
2020 |
Hyperhomocysteinemia
|
disease |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
|
Disease or Syndrome
|
246
|
45
|
0.400 |
None |
0.927 |
273 |
6
|
1995 |
2019 |
Colorectal Carcinoma
|
disease |
Digestive System Diseases; Neoplasms
|
Neoplastic Process
|
5473
|
1962
|
0.400 |
None |
0.932 |
118 |
12
|
1996 |
2019 |
Neural Tube Defects
|
group |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
|
Congenital Abnormality
|
304
|
122
|
0.400 |
None |
0.914 |
105 |
5
|
1995 |
2019 |
Malignant neoplasm of breast
|
disease |
Neoplasms; Skin and Connective Tissue Diseases
|
Neoplastic Process
|
6941
|
3417
|
0.400 |
None |
0.890 |
100 |
10
|
2002 |
2020 |
Breast Carcinoma
|
disease |
Neoplasms; Skin and Connective Tissue Diseases
|
Neoplastic Process
|
6776
|
2793
|
0.400 |
None |
0.890 |
100 |
10
|
2002 |
2020 |
Cardiovascular Diseases
|
group |
Cardiovascular Diseases
|
Disease or Syndrome
|
1756
|
711
|
0.400 |
None |
0.923 |
91 |
6
|
1996 |
2020 |
Childhood Acute Lymphoblastic Leukemia
|
disease |
Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
|
Neoplastic Process
|
1096
|
261
|
0.400 |
None |
0.917 |
72 |
8
|
1999 |
2020 |
Thrombophilia
|
disease |
Hemic and Lymphatic Diseases
|
Disease or Syndrome
|
161
|
43
|
0.400 |
None |
0.873 |
55 |
6
|
1999 |
2019 |
Rheumatoid Arthritis
|
disease |
Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
|
Disease or Syndrome
|
2723
|
2387
|
0.400 |
None |
0.923 |
52 |
6
|
2001 |
2018 |
Down Syndrome
|
disease |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
|
Disease or Syndrome
|
766
|
80
|
0.400 |
None |
0.878 |
49 |
4
|
1999 |
2019 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
disease |
Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
|
Neoplastic Process
|
879
|
168
|
0.400 |
None |
0.978 |
45 |
2
|
1999 |
2019 |