Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
0.060 Biomarker group BEFREE Here, we used clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein 9 (Cas9) genome editing to demonstrate that the dsDNA receptor <u>a</u>bsent <u>i</u>n <u>m</u>elanoma 2 (AIM2) is required for secretion of IL-1β following HCMV infection. 30755509 2019
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
0.060 Biomarker group BEFREE Furthermore, caspase-1 activation was compromised in bone marrow-derived macrophages lacking GSDMD stimulated with other AIM2 inflammasome triggers, including poly(dA:dT) transfection and mouse CMV infection. 30404813 2018
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
0.060 AlteredExpression group BEFREE To determine whether pUL83 contributes to the variation in AIM2 levels during HCMV infection, we investigated the pUL83/AIM2 interaction and its impact on the AIM2 inflammasome activation. 28219398 2017
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
0.060 Biomarker group BEFREE In addition, AIM2-defiecient cells were unable to efficiently control HCMV infection, as the transcription of virus DNA polymerase gene UL54 and major tegument protein gene UL83 were higher compared to wild-type cells. 28480966 2017
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
0.060 Biomarker group BEFREE Finally, CRISPR-mediated disruption of the human AIM2-like receptor IFI16 in primary fibroblasts revealed that IFI16 is not essential for the IFN response to human cytomegalovirus infection. 27496731 2016
Entrez Id: 9447
Gene Symbol: AIM2
AIM2
0.060 Biomarker group BEFREE Moreover, production of IL-18 and natural killer cell-dependent production of interferon-gamma, events critical in the early control of virus replication, were dependent on AIM2 during mouse cytomegalovirus infection in vivo. 20351692 2010