Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE 1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression. 31022424 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE COX-2 overexpression was observed in 12 of 77 (15.6%) DP and there was no significant difference between DPdep (3 of 23, 13.0%) and DPpo (9 of 54, 16.7%). 12397273 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease PSYGENET Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE AD and depression are crucially linked by neuroinflammation and cyclooxygenase II (COX-2) enzyme involvement is an intriguing field of research. 29879605 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE An imbalance in the cortical COX2-PGE2-cAMP/PKA-CREB-BDNF signalling pathway participates in the pathogenic mechanism of depression. 28352129 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. 28108057 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease CTD_human Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression. 19356723 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease PSYGENET Genetic variations in the COX2 and PLA2 genes increase the risk of IFN-alpha-induced depression, possibly by affecting the levels of EPA and DHA. 20034614 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression. 30526621 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 GeneticVariation disease BEFREE Participants with the PLA2 BanI GG or the COX2 rs4648308 AG genotypes had a higher risk of IFN-alpha-induced depression (odds ratio = 3.1 and 3.5, respectively). 20034614 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group had no correlation with the existence of lumps and localized density-increased shadows (p>0.05), but were associated with manifestations of architectural distortion, calcification as well as skin and nipple depression (p<0.05). 28927045 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease PSYGENET Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 GeneticVariation disease BEFREE Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease PSYGENET The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. 22331023 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE The potential of various anti-inflammatory approaches such as selective cyclooxygenase-2 inhibitors, inflammatory cytokine inhibitors, and indoleamine 2,3-dioxygenase inhibitors pertaining to their serotonin restoring effects is discussed as possible therapy for treatment of depression in epilepsy. 28038393 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease PSYGENET There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE These findings suggest that selective inhibition of COX-2 ameliorates depression-like behaviors in rat models of depression. 31539536 2019