Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE IGF-II-Conjugated Nanocarrier for Brain-Targeted Delivery of p11 Gene for Depression. 30617637 2019
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE The molecular associations of depression behavior with anxiety and memory deficit suggested a potential approach to improve therapeutic intervention through P11 in these disorders. 31337969 2019
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE Reviewing the literature concerning BNDF, p11 and Homer1a we here describe a molecular network in which these molecules interact with each other finally leading to facilitation of AMPA receptor signaling and plasticity, corroborating the current idea of AMPA receptors being a promising drug target in depression. 29550211 2018
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE These results have identified p11 in LHb as a key molecular determinant regulating negative emotions, which may help to understand the molecular and cellular basis of depression. 28507317 2018
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 AlteredExpression disease BEFREE Our results have identified p11 as a key molecule in a specific cell type that regulates stress-induced depression, which provides a framework for the development of new strategies to treat stress-associated mental illnesses. 27457815 2017
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 AlteredExpression disease BEFREE Monocyte, natural killer (NK) cell, and cytotoxic T-cell p11 levels were positively associated with the severity of PD, and NK cell p11 levels were positively associated with depression scores. 28137881 2017
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression. 26821757 2016
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study. 22990943 2013
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease CTD_human In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment. 21682946 2012
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease PSYGENET P11 expression and PET in bipolar disorders. 21722919 2011
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 AlteredExpression disease BEFREE Understanding the chromatin remodeling involved in the glucocorticoid-mediated increase of p11 expression by stress may clarify stress-induced over-expression of p11 and also identify a new therapeutic target for post-traumatic disorder and depressive disorders, i.e., chromatin remodeling. 21367534 2011
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease PSYGENET Understanding the chromatin remodeling involved in the glucocorticoid-mediated increase of p11 expression by stress may clarify stress-induced over-expression of p11 and also identify a new therapeutic target for post-traumatic disorder and depressive disorders, i.e., chromatin remodeling. 21367534 2011
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE Taken together, the data suggest that gene therapies aimed at enhancing p11 in the NAcc may represent promising new approaches for treating depression; however, a large number of clinical and regulatory issues must be overcome before such therapies can be implemented. 20962329 2010
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 AlteredExpression disease BEFREE Previously, it has been found that p11 mRNA expression was significantly changed in post mortem cortex of patients with PTSD and depression. 19380152 2009
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 Biomarker disease BEFREE A review of the literature provides strong evidence that 5-HT(1B) receptors and related factors such as p11 are involved in the pathophysiology of depression. 19702551 2009
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 AlteredExpression disease BEFREE Recently, a study demonstrated that dexamethasone (Dex), a synthetic glucocorticoid, can up-regulate p11, known as S100A10-protein which is down-regulated in patients with depression, (Yao et al., 1999; Huang et al., 2003) a common comorbid disorder in PTSD. 18440154 2008
Entrez Id: 6281
Gene Symbol: S100A10
S100A10
0.600 AlteredExpression disease BEFREE Furthermore, brain p11 mRNA expression is lower in post mortem brains from patients who were suffering from depression and had committed suicide compared with control subjects who had died from other causes.