Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 Biomarker disease BEFREE An antipeptide antibody raised against the C-terminus of the TCF4 poly-cysteine frame recognized RAN translation products by IF in cells transfected with CTG·CAG repeats and in FECD corneal endothelium. 29677349 2018
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 GeneticVariation disease BEFREE Analysis of SLC4A11, ZEB1, LOXHD1, COL8A2 and TCF4 gene sequences in a multi-generational family with late-onset Fuchs corneal dystrophy. 27121161 2016
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 Biomarker disease BEFREE Analysis of the diagnostic performance of individual markers in TCF4 and their combinations showed that the CTG18.1 repeat expansion was the best classifier for FECD (AUC = 0.84). 30267097 2018
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 PosttranslationalModification disease BEFREE Association and familial segregation of CTG18.1 trinucleotide repeat expansion of TCF4 gene in Fuchs' endothelial corneal dystrophy. 24255041 2014
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 GeneticVariation disease BEFREE Association of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese. 21659310 2011
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 GeneticVariation disease BEFREE Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process. 22234156 2012
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 GeneticVariation disease BEFREE Association of TCF4 polymorphisms and Fuchs' endothelial dystrophy: a meta-analysis. 26087656 2015
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 GeneticVariation disease BEFREE Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review and meta-analysis. 25299301 2014
Entrez Id: 5793
Gene Symbol: PTPRG
PTPRG
0.110 GeneticVariation disease BEFREE Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review and meta-analysis. 25299301 2014
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 GeneticVariation disease BEFREE Association of single nucleotide polymorphisms (SNPs) and CTG trinucleotide repeat expansions in the intron of TCF4 gene to FECD has been studied across multiple ethnicities. 29799290 2018
Entrez Id: 1191
Gene Symbol: CLU
CLU
0.040 GeneticVariation disease BEFREE Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process. 22234156 2012
Entrez Id: 7045
Gene Symbol: TGFBI
TGFBI
0.040 GeneticVariation disease BEFREE Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process. 22234156 2012
Entrez Id: 83959
Gene Symbol: SLC4A11
SLC4A11
0.400 GeneticVariation disease BEFREE Biosynthetic and functional defects in newly identified SLC4A11 mutants and absence of COL8A2 mutations in Fuchs endothelial corneal dystrophy. 25007886 2014
Entrez Id: 1296
Gene Symbol: COL8A2
COL8A2
0.600 GeneticVariation disease BEFREE Biosynthetic and functional defects in newly identified SLC4A11 mutants and absence of COL8A2 mutations in Fuchs endothelial corneal dystrophy. 25007886 2014
Entrez Id: 1351
Gene Symbol: COX8A
COX8A
0.010 Biomarker disease BEFREE Collagen VIII mutations, which clinically result in Fuchs' dystrophy, are associated with abnormal cellular accumulation of collagen VIII. 22020132 2011
Entrez Id: 7045
Gene Symbol: TGFBI
TGFBI
0.040 Biomarker disease BEFREE Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy. 19011008 2009
Entrez Id: 1191
Gene Symbol: CLU
CLU
0.040 Biomarker disease BEFREE Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy. 19011008 2009
Entrez Id: 407024
Gene Symbol: MIR29B1
MIR29B1
0.010 AlteredExpression disease BEFREE Compared with control, miR-29b expression level after transfection of iFECD was increased to 335.6% (±91.0%), and ECM expression levels were significantly decreased. 27490049 2016
Entrez Id: 407025
Gene Symbol: MIR29B2
MIR29B2
0.010 AlteredExpression disease BEFREE Compared with control, miR-29b expression level after transfection of iFECD was increased to 335.6% (±91.0%), and ECM expression levels were significantly decreased. 27490049 2016
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 Biomarker disease BEFREE Considering a 75% prevalence of TCF4 TNR expansion in FECD, the probability of four FECD probands lacking TNR expansion was 0.4%. 30025114 2018
Entrez Id: 6935
Gene Symbol: ZEB1
ZEB1
0.600 GeneticVariation disease BEFREE Conversely, as the reported ZEB1 missense mutations do not significantly impact protein abundance or nuclear localization, the effect of these mutations on ZEB1 function and their relationship to FECD, if any, remain to be elucidated. 25190660 2014
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.010 Biomarker disease BEFREE Correspondingly, DICER1, (encoding an endoribonuclease critical to miRNA biogenesis) showed a moderate but significant decrease in FECD samples (P < 0.05). 24334445 2014
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 Biomarker disease BEFREE CRISPR/Cas9-targeted enrichment and long-read sequencing of the Fuchs endothelial corneal dystrophy-associated TCF4 triplet repeat. 30733599 2019
Entrez Id: 6925
Gene Symbol: TCF4
TCF4
0.500 Biomarker disease BEFREE CTG18.1 Expansion in TCF4 Among African Americans With Fuchs' Corneal Dystrophy. 29196769 2017
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
0.010 Biomarker disease BEFREE Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy. 22836768 2012