Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.030 Biomarker disease BEFREE The IL-33-induced production of pro-inflammatory cytokines is a critical event that aggravates atopic diseases such as asthma, atopic dermatitis, and pollenosis and suggests that IL-33-blocking agents could represent new therapeutic drugs. 25213717 2014
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.030 AlteredExpression disease BEFREE Allergen induced mRNA expression of interleukin-5, but not of interleukin-4 and interferon-gamma, in peripheral blood mononuclear cells obtained before the pollen season predicts the clinical efficacy of immunotherapy for seasonal allergic rhinitis. 10652165 2000
Entrez Id: 3269
Gene Symbol: HRH1
HRH1
0.030 AlteredExpression disease BEFREE H1R mRNA was significantly elevated in epithelial (P<0.001) and mucus cells (P<0.05) of PAR in comparison with non-AR whereas H1R gene expression levels in endothelial cells between both groups were not changed (P=0.23). 16297140 2005
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.030 GeneticVariation disease BEFREE Of 60 tagging single-nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR: 1.5; 95% CI: 1.0-2.3; P = 0.04), CSF2RB rs16997517 (dominant OR: 2.2; 95% CI: 1.0-4.7; P = 0.04), and IL13 rs1800925 (per-allele OR: 1.7; 95% CI: 1.3-2.4; P = 0.0007). 21071541 2011
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.030 GeneticVariation disease BEFREE We cultured human nasal mucosa obtained from individuals with seasonal allergic rhinitis with either specific allergen, recombinant human IL-5 (rhIL-5), or allergen + soluble IL-5Ralpha (sIL-5Ralpha), shown to antagonize IL-5 function. 10640772 2000
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.030 Biomarker disease BEFREE Our results support a role for IL-33 in the pathogenesis of JC pollinosis. 19037964 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.030 GeneticVariation disease BEFREE Our data suggest lack of evidence for identifying the variant Arg110Glnat the IL13 locus as a genetic risk factor involved in the development of Japanese cedar pollinosis. 16272823 2006
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.030 GeneticVariation disease BEFREE IL-33-polymorphisms rs928413 and rs1342326 may account for an increased risk of hay fever with the age of 6 years. 27171815 2016
Entrez Id: 3566
Gene Symbol: IL4R
IL4R
0.020 Biomarker disease BEFREE After diagnosing 351 subjects on the basis of an intradermal test, nasal provocation test, and questionnaire regarding nasal and conjunctival symptoms, we determined the blood-specific IgE values and genotypes of eosinophil peroxidase (EPO) and interleukin-4 receptor alpha-chain (IL4RA) in 145 patients with pollinosis and 206 healthy subjects, including 75 healthy subjects with higher specific IgE values. 14657871 2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 Biomarker disease BEFREE Allergen induced mRNA expression of interleukin-5, but not of interleukin-4 and interferon-gamma, in peripheral blood mononuclear cells obtained before the pollen season predicts the clinical efficacy of immunotherapy for seasonal allergic rhinitis. 10652165 2000
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.020 GeneticVariation disease BEFREE Our comprehensive screening suggested that population-specific FLG mutations may be a significant predisposing factor for hay fever (odds ratio = 2.01 [95% CI: 1.027-3.936, P < 0.05]), although the sample sizes of this study were too small for reliable subphenotype analysis on the association between FLG mutations and hay fever in the eczema patients and the noneczema individuals, and it is not clear whether the association between FLG mutations and hay fever is due to the close association between FLG mutations and hay fever patients with eczema. 24467288 2014
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.020 Biomarker disease BEFREE Grass pollen-driven T<sub>H</sub>2 cell proliferation and cytokine production were measured by using tritiated thymidine and Luminex MagPix, respectively. iT<sub>R</sub>35 cells were quantified in patients with grass pollen allergy (seasonal allergic rhinitis [SAR] group, n = 16), sublingual immunotherapy (SLIT)-treated patients (SLIT group, n = 16), and nonatopic control subjects (NACs; NAC group, n = 16). 30053528 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 AlteredExpression disease BEFREE The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. 30860439 2019
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease LHGDN Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 3566
Gene Symbol: IL4R
IL4R
0.020 GeneticVariation disease BEFREE The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis. 21918367 2012
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.020 Biomarker disease BEFREE Allergen induced mRNA expression of interleukin-5, but not of interleukin-4 and interferon-gamma, in peripheral blood mononuclear cells obtained before the pollen season predicts the clinical efficacy of immunotherapy for seasonal allergic rhinitis. 10652165 2000
Entrez Id: 3725
Gene Symbol: JUN
JUN
0.020 Biomarker disease BEFREE FOS, JUN, and DUSP1 could be used as candidate targets for the treatment of seasonal allergic rhinitis (SAR) during the pollen season, while KLF4 and CD163 could be used as candidate targets outside the pollen season. 26189617 2015
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE These results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis. 14657871 2003
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 GeneticVariation disease BEFREE We found decreased OR for hayfever (OR=0.60, 95%CI=0.4-0.9) and sensitization to inhalant antigens (OR=0.5, 95%CI=0.4-0.8) in heterozygotes of the IL-6 -174 G/C polymorphism. 15005726 2004
Entrez Id: 3725
Gene Symbol: JUN
JUN
0.020 Biomarker disease BEFREE Several genes related to immunity and regulation of transcription, such as FOS, JUN, and CEBPD, may play crucial roles during the process of SAR through the interactions with each other. 27435592 2017
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. 24751681 2014
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.020 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 6356
Gene Symbol: CCL11
CCL11
0.020 AlteredExpression disease BEFREE Oral administration of levocetirizine for four weeks also reduced RANTES and eotaxin levels in nasal secretions from patients with pollinosis, along with attenuation of clinical symptoms. 24982238 2015
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 Biomarker disease BEFREE High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis. 14657871 2003
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004