Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. 24751681 2014
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. 15298558 2004
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.020 GeneticVariation disease BEFREE Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. 19839980 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.020 GeneticVariation disease BEFREE Our objective was to determine the frequency of TNF-alpha -238, -308 G/A promoter and TLR-4 299 D/G and 399 T/I polymorphisms in healthy population and in patients with seasonal allergic rhinitis, and to examine its influences on serum TNF-alpha, TNF receptor-1, Fas, Fas-ligand, IgE levels and on clinical symptoms. 21103885 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.020 GeneticVariation disease BEFREE Among the correlations with the clinical parameters, we observed an increased risk of allergies (odds ratio, OR= 4.1; confidence interval, CI: 1.6-10.4), particularly hay fever (OR=5.6, CI: 1.8-17.1) in individuals homozygous for IFNG 13 CA-repeats. 11354638 2001
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.020 GeneticVariation disease BEFREE After controlling for age group and sex using logistic regression, the odds of having hay fever were reduced by 88% (P = .009) in the TLR4 polymorphic group compared with the wild-type group. 18517079 2008
Entrez Id: 2829
Gene Symbol: XCR1
XCR1
0.010 GeneticVariation disease BEFREE We sequenced CCR1, CCR2, CCR3, CCR5, and CCXCR1 using the PCR restriction fragment length polymorphism method in subjects with cedar pollinosis and controls. 17135764 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 GeneticVariation disease BEFREE In combination with the TNF wildtype, the risk for hay fever increased to OR=8.4 (CI: 2.7-25.6). 11354638 2001
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 GeneticVariation disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 28
Gene Symbol: ABO
ABO
0.010 GeneticVariation disease BEFREE Associations between blood groups and RAD (atopic bronchial asthma [ABA] and pollinosis), the severity of the disease and the type of sensitization were established, involving the ABO, MNSs and Duffy systems. 7551203 1995
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.010 GeneticVariation disease BEFREE The objective of this study was to investigate whether SNPs of the MMP9 gene are associated with risk of seasonal AR (pollinosis), perennial AR and allergen sensitization. 22237587 2012
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.010 GeneticVariation disease BEFREE We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence. 27043549 2016
Entrez Id: 931
Gene Symbol: MS4A1
MS4A1
0.010 GeneticVariation disease BEFREE An important locus for Atopy (familial asthma, hay fever and eczema) has been localized to the 11q12-q13 region with the minimum recombination fraction around the CD20 gene. 7521709 1994
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.010 GeneticVariation disease BEFREE The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported. 30209858 2019
Entrez Id: 9021
Gene Symbol: SOCS3
SOCS3
0.010 GeneticVariation disease BEFREE Lower Tregs and increased SOCS3 in combined heterozygotes and minor allele homozygotes may be relevant for hay fever development, pointing towards dysbalanced immune regulation and insufficient control of allergic inflammation. 27171815 2016
Entrez Id: 4586
Gene Symbol: MUC5AC
MUC5AC
0.010 GeneticVariation disease BEFREE Statistically significant associations between the 3'ter MUC5AC simple nucleotide polymorphism (SNP) rs1132440 and various non-independent respiratory outcomes (bronchitis, wheeze, asthma, hay fever) were reported while the adjacent loci show slight (but largely non-statistically significant) differences, presumably reflective of linkage disequilibrium (allelic association) across the region. 23551418 2013
Entrez Id: 28955
Gene Symbol: DEXI
DEXI
0.010 GeneticVariation disease BEFREE The rs62026376:C allele associated with increased asthma with hay fever risk has been found to be associated also with decreased expression of the nearby DEXI gene in monocytes. 24388013 2014
Entrez Id: 54474
Gene Symbol: KRT20
KRT20
0.010 GeneticVariation disease BEFREE An important locus for Atopy (familial asthma, hay fever and eczema) has been localized to the 11q12-q13 region with the minimum recombination fraction around the CD20 gene. 7521709 1994
Entrez Id: 3126
Gene Symbol: HLA-DRB4
HLA-DRB4
0.010 GeneticVariation disease BEFREE The HLA variant rs7775228, which cis-regulates HLA-DRB4, was strongly associated with grass sensitization and weakly with AR (P(grass) = 1.6 × 10(-9); P(AR) = 8.0 × 10(-3)). 22036096 2011
Entrez Id: 7593
Gene Symbol: MZF1
MZF1
0.010 GeneticVariation disease BEFREE Self-reported histories of hay fever and asthma were obtained from 3,808 pairs of adult twins 18 years and over registered with the Australian National Health Medical Research Council Twin Registry (1232 MZF, 567 MZM, 751 DZF, 352 DZM, 906 DZO). 2227373 1990
Entrez Id: 1439
Gene Symbol: CSF2RB
CSF2RB
0.010 GeneticVariation disease BEFREE CSF2RB rs16997517 was directly related to pollen allergies in controls and to reduced SCC risk. 21071541 2011
Entrez Id: 119710
Gene Symbol: IFTAP
IFTAP
0.010 GeneticVariation disease BEFREE In the present study, CCSNOP or control (non-woven cloth; NWC) panels were placed in the bedrooms of pollen allergy patients for two weeks during the pollen dispersal season in 2018, and the effects were investigated. 31817806 2019
Entrez Id: 2615
Gene Symbol: LRRC32
LRRC32
0.010 GeneticVariation disease BEFREE A variant near LRRC32 was a stronger risk factor for hay fever than for asthma, whereas the reverse was observed for variants in/near GSDMA and TSLP. 24388013 2014
Entrez Id: 7356
Gene Symbol: SCGB1A1
SCGB1A1
0.010 GeneticVariation disease BEFREE For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns. 19222419 2009