Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1469
Gene Symbol: CST1
CST1
0.320 AlteredExpression disease BEFREE Immunohistochemical staining confirmed the increased expression of CST1 in the nasal epithelial cells of SAR patients. 23950865 2013
Entrez Id: 1483
Gene Symbol: CTAA1
CTAA1
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 GeneticVariation disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 6373
Gene Symbol: CXCL11
CXCL11
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 4283
Gene Symbol: CXCL9
CXCL9
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 10800
Gene Symbol: CYSLTR1
CYSLTR1
0.010 Biomarker disease BEFREE We examined the expression of the proteins involved in the synthesis of CysLTs and the cysteinyl leukotriene-1 (CysLT1) and cysteinyl leukotriene-2 (CysLT2) receptors in inflammatory cells from patients with active seasonal allergic rhinitis. 14519144 2003
Entrez Id: 57105
Gene Symbol: CYSLTR2
CYSLTR2
0.010 Biomarker disease BEFREE We examined the expression of the proteins involved in the synthesis of CysLTs and the cysteinyl leukotriene-1 (CysLT1) and cysteinyl leukotriene-2 (CysLT2) receptors in inflammatory cells from patients with active seasonal allergic rhinitis. 14519144 2003
Entrez Id: 28955
Gene Symbol: DEXI
DEXI
0.010 GeneticVariation disease BEFREE The rs62026376:C allele associated with increased asthma with hay fever risk has been found to be associated also with decreased expression of the nearby DEXI gene in monocytes. 24388013 2014
Entrez Id: 1843
Gene Symbol: DUSP1
DUSP1
0.010 Biomarker disease BEFREE FOS, JUN, and DUSP1 could be used as candidate targets for the treatment of seasonal allergic rhinitis (SAR) during the pollen season, while KLF4 and CD163 could be used as candidate targets outside the pollen season. 26189617 2015
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.010 Biomarker disease LHGDN We conclude that endothelin-1 could be involved in the pathogenesis of seasonal allergic rhinitis. 18260253 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.010 AlteredExpression disease LHGDN Epidermal growth factor receptor - but not histamine receptor - is upregulated in seasonal allergic rhinitis. 12757445 2003
Entrez Id: 5169
Gene Symbol: ENPP3
ENPP3
0.010 AlteredExpression disease BEFREE This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time-of-day-dependent variation associated with temporal variations in canonical circadian clock gene expression. 25443426 2015
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease LHGDN Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE These results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis. 14657871 2003
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
0.010 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.020 GeneticVariation disease BEFREE Our comprehensive screening suggested that population-specific FLG mutations may be a significant predisposing factor for hay fever (odds ratio = 2.01 [95% CI: 1.027-3.936, P < 0.05]), although the sample sizes of this study were too small for reliable subphenotype analysis on the association between FLG mutations and hay fever in the eczema patients and the noneczema individuals, and it is not clear whether the association between FLG mutations and hay fever is due to the close association between FLG mutations and hay fever patients with eczema. 24467288 2014
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.020 GeneticVariation disease BEFREE Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. 19839980 2009
Entrez Id: 2316
Gene Symbol: FLNA
FLNA
0.010 Biomarker disease BEFREE Associations between blood groups and RAD (atopic bronchial asthma [ABA] and pollinosis), the severity of the disease and the type of sensitization were established, involving the ABO, MNSs and Duffy systems. 7551203 1995
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.010 AlteredExpression disease BEFREE Notably, the change of FOXP3 gene expression in donors showing peptide-specific T-helper responses was significantly lower than that in nonresponders, regardless of allergic pollinosis. 19178794 2009
Entrez Id: 113263
Gene Symbol: GLCCI1
GLCCI1
0.010 Biomarker disease BEFREE MATERIAL AND METHODS In this study, 286 Chinese Han patients with SAR were genotyped for 4 candidate genes: the glucocorticosteroid receptor (NR3C1) gene, glucocorticoid-induced transcription factor 1 (GLCCI1) gene, T-box 21 gene (TBX21), and ATP binding cassette subfamily B member 1 (ABCB1) gene. 29981236 2018
Entrez Id: 27239
Gene Symbol: GPR162
GPR162
0.010 Biomarker disease BEFREE Resistance to RAD was associated with phenotypes A(II), AB(IV), N, Fya(+) and B(III)N. Markers for ABA and pollinosis were also revealed. 7551203 1995
Entrez Id: 284110
Gene Symbol: GSDMA
GSDMA
0.100 GeneticVariation disease GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.010 GeneticVariation disease BEFREE We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence. 27043549 2016
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
0.010 GeneticVariation disease BEFREE We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence. 27043549 2016