Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE These results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis. 14657871 2003
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 GeneticVariation disease BEFREE We found decreased OR for hayfever (OR=0.60, 95%CI=0.4-0.9) and sensitization to inhalant antigens (OR=0.5, 95%CI=0.4-0.8) in heterozygotes of the IL-6 -174 G/C polymorphism. 15005726 2004
Entrez Id: 3725
Gene Symbol: JUN
JUN
0.020 Biomarker disease BEFREE Several genes related to immunity and regulation of transcription, such as FOS, JUN, and CEBPD, may play crucial roles during the process of SAR through the interactions with each other. 27435592 2017
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE The ADAM33 gene has been identified as a potentially important asthma candidate gene and polymorphisms in this gene have been shown to be associated with asthma and seasonal allergic rhinitis. 24751681 2014
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.020 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 6356
Gene Symbol: CCL11
CCL11
0.020 AlteredExpression disease BEFREE Oral administration of levocetirizine for four weeks also reduced RANTES and eotaxin levels in nasal secretions from patients with pollinosis, along with attenuation of clinical symptoms. 24982238 2015
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 Biomarker disease BEFREE High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis. 14657871 2003
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 55540
Gene Symbol: IL17RB
IL17RB
0.020 AlteredExpression disease BEFREE Among these 3 genes, the expression of interleukin 17 receptor beta (IL17RB) was confirmed to be upregulated in SAR patients compared to that of the IL17RB gene in healthy, non-allergic controls. 21252617 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 Biomarker disease BEFREE We studied the role of IL-10 in the induction of clinical, cellular, and humoral tolerance during immunotherapy for local mucosal allergy in subjects with seasonal pollinosis. 14978133 2004
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. 15298558 2004
Entrez Id: 2312
Gene Symbol: FLG
FLG
0.020 GeneticVariation disease BEFREE Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear. 19839980 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.020 GeneticVariation disease BEFREE Our objective was to determine the frequency of TNF-alpha -238, -308 G/A promoter and TLR-4 299 D/G and 399 T/I polymorphisms in healthy population and in patients with seasonal allergic rhinitis, and to examine its influences on serum TNF-alpha, TNF receptor-1, Fas, Fas-ligand, IgE levels and on clinical symptoms. 21103885 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.020 GeneticVariation disease BEFREE Among the correlations with the clinical parameters, we observed an increased risk of allergies (odds ratio, OR= 4.1; confidence interval, CI: 1.6-10.4), particularly hay fever (OR=5.6, CI: 1.8-17.1) in individuals homozygous for IFNG 13 CA-repeats. 11354638 2001
Entrez Id: 6356
Gene Symbol: CCL11
CCL11
0.020 AlteredExpression disease BEFREE Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. 9409555 1997
Entrez Id: 55540
Gene Symbol: IL17RB
IL17RB
0.020 AlteredExpression disease BEFREE PBMCs from 11 patients with SAR and 23 healthy controls were analysed with gene expression profiling. mRNA expression of IL17RB in basophils was evaluated using quantitative real-time PCR. 20545698 2010
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.020 GeneticVariation disease BEFREE After controlling for age group and sex using logistic regression, the odds of having hay fever were reduced by 88% (P = .009) in the TLR4 polymorphic group compared with the wild-type group. 18517079 2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 AlteredExpression disease BEFREE Increased BDI-II scores in SAR patients were significantly associated with levels of IL-6 as well as IL-6/IL-10 and IFN-γ/IL-10 ratios and further, to an early age at manifestation of SAR and poor sleep quality. 28495610 2017
Entrez Id: 2829
Gene Symbol: XCR1
XCR1
0.010 GeneticVariation disease BEFREE We sequenced CCR1, CCR2, CCR3, CCR5, and CCXCR1 using the PCR restriction fragment length polymorphism method in subjects with cedar pollinosis and controls. 17135764 2007
Entrez Id: 6351
Gene Symbol: CCL4
CCL4
0.010 AlteredExpression disease BEFREE Analysis of nasal fluid CCL4 protein confirmed lower levels in women with seasonal allergic rhinitis, before and during the pollen season. 18440239 2008
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.010 AlteredExpression disease BEFREE This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time-of-day-dependent variation associated with temporal variations in canonical circadian clock gene expression. 25443426 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 GeneticVariation disease BEFREE In combination with the TNF wildtype, the risk for hay fever increased to OR=8.4 (CI: 2.7-25.6). 11354638 2001
Entrez Id: 4283
Gene Symbol: CXCL9
CXCL9
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 64806
Gene Symbol: IL25
IL25
0.010 Biomarker disease BEFREE The IL-25 concentration in nasal secretions was significantly higher in patients with Japanese cedar pollinosis than in HCs. 29402661 2018
Entrez Id: 1811
Gene Symbol: SLC26A3
SLC26A3
0.010 Biomarker disease BEFREE The RESPOS2 has confirmed previous reports that CLD in PBs <30 weeks GA is not associated with the development of childhood asthma, hay fever or eczema. 28902527 2018