Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3566
Gene Symbol: IL4R
IL4R
0.020 Biomarker disease BEFREE After diagnosing 351 subjects on the basis of an intradermal test, nasal provocation test, and questionnaire regarding nasal and conjunctival symptoms, we determined the blood-specific IgE values and genotypes of eosinophil peroxidase (EPO) and interleukin-4 receptor alpha-chain (IL4RA) in 145 patients with pollinosis and 206 healthy subjects, including 75 healthy subjects with higher specific IgE values. 14657871 2003
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE These results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis. 14657871 2003
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 Biomarker disease BEFREE High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis. 14657871 2003
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 Biomarker disease BEFREE We studied the role of IL-10 in the induction of clinical, cellular, and humoral tolerance during immunotherapy for local mucosal allergy in subjects with seasonal pollinosis. 14978133 2004
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.110 GeneticVariation disease BEFREE Homozygotes of the G-allele in IL-2 -330 T/G were at increased risk of hayfever (OR=2.6, 95%CI=1.3-5.2). 15005726 2004
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 GeneticVariation disease BEFREE We found decreased OR for hayfever (OR=0.60, 95%CI=0.4-0.9) and sensitization to inhalant antigens (OR=0.5, 95%CI=0.4-0.8) in heterozygotes of the IL-6 -174 G/C polymorphism. 15005726 2004
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.010 GeneticVariation disease BEFREE Our data suggest an association of genetic variants in IL-6 and IL-2 with hayfever, confirm a role of polymorphisms in IL-4R, IL-13, and IL-18 for the elevated IgE phenotype, and add IL-6 to the list of candidate genes. 15005726 2004
Entrez Id: 5319
Gene Symbol: PLA2G1B
PLA2G1B
0.010 AlteredExpression disease BEFREE The mRNA levels of PLA2 VIIA (platelet-activating factor (PAF) acetylhydrolase) were lower in SAR patients than controls, both during pollen season (p = 0.03) and off season (p = 0.03). 15224635 2004
Entrez Id: 7534
Gene Symbol: YWHAZ
YWHAZ
0.010 AlteredExpression disease BEFREE Phospholipase A2 mRNA expression in the nasal mucosa of healthy subjects and patients with seasonal allergic rhinitis. 15224635 2004
Entrez Id: 9768
Gene Symbol: PCLAF
PCLAF
0.010 Biomarker disease BEFREE The observation that PAF acetylhydrolase mRNA expression in the nasal mucosa is lower in SAR patients than in healthy subjects suggests the possibility that impaired ability to inactivate PAF might be of importance in SAR. 15224635 2004
Entrez Id: 151056
Gene Symbol: PLB1
PLB1
0.010 AlteredExpression disease BEFREE Phospholipase A2 mRNA expression in the nasal mucosa of healthy subjects and patients with seasonal allergic rhinitis. 15224635 2004
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. 15298558 2004
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease LHGDN Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 4283
Gene Symbol: CXCL9
CXCL9
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 GeneticVariation disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 55153
Gene Symbol: SDAD1
SDAD1
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 6373
Gene Symbol: CXCL11
CXCL11
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.030 GeneticVariation disease BEFREE Our data suggest lack of evidence for identifying the variant Arg110Glnat the IL13 locus as a genetic risk factor involved in the development of Japanese cedar pollinosis. 16272823 2006
Entrez Id: 3269
Gene Symbol: HRH1
HRH1
0.030 AlteredExpression disease BEFREE H1R mRNA was significantly elevated in epithelial (P<0.001) and mucus cells (P<0.05) of PAR in comparison with non-AR whereas H1R gene expression levels in endothelial cells between both groups were not changed (P=0.23). 16297140 2005
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.020 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 55065
Gene Symbol: SLC52A1
SLC52A1
0.010 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
0.010 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 2829
Gene Symbol: XCR1
XCR1
0.010 GeneticVariation disease BEFREE We sequenced CCR1, CCR2, CCR3, CCR5, and CCXCR1 using the PCR restriction fragment length polymorphism method in subjects with cedar pollinosis and controls. 17135764 2007
Entrez Id: 729230
Gene Symbol: CCR2
CCR2
0.010 Biomarker disease BEFREE Our results suggest that CCR2 and CCR3 genes are candidate genes for Japanese cedar pollinosis. 17135764 2007