Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.010 AlteredExpression disease LHGDN Epidermal growth factor receptor - but not histamine receptor - is upregulated in seasonal allergic rhinitis. 12757445 2003
Entrez Id: 57105
Gene Symbol: CYSLTR2
CYSLTR2
0.010 Biomarker disease BEFREE We examined the expression of the proteins involved in the synthesis of CysLTs and the cysteinyl leukotriene-1 (CysLT1) and cysteinyl leukotriene-2 (CysLT2) receptors in inflammatory cells from patients with active seasonal allergic rhinitis. 14519144 2003
Entrez Id: 10800
Gene Symbol: CYSLTR1
CYSLTR1
0.010 Biomarker disease BEFREE We examined the expression of the proteins involved in the synthesis of CysLTs and the cysteinyl leukotriene-1 (CysLT1) and cysteinyl leukotriene-2 (CysLT2) receptors in inflammatory cells from patients with active seasonal allergic rhinitis. 14519144 2003
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.110 GeneticVariation disease BEFREE Homozygotes of the G-allele in IL-2 -330 T/G were at increased risk of hayfever (OR=2.6, 95%CI=1.3-5.2). 15005726 2004
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease LHGDN Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.020 GeneticVariation disease BEFREE We found decreased OR for hayfever (OR=0.60, 95%CI=0.4-0.9) and sensitization to inhalant antigens (OR=0.5, 95%CI=0.4-0.8) in heterozygotes of the IL-6 -174 G/C polymorphism. 15005726 2004
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.020 GeneticVariation disease BEFREE Our results might indicate that polymorphisms of the EPO gene are associated with Japanese cedar pollinosis. 15316147 2004
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 Biomarker disease BEFREE We studied the role of IL-10 in the induction of clinical, cellular, and humoral tolerance during immunotherapy for local mucosal allergy in subjects with seasonal pollinosis. 14978133 2004
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.020 GeneticVariation disease BEFREE In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. 15298558 2004
Entrez Id: 5319
Gene Symbol: PLA2G1B
PLA2G1B
0.010 AlteredExpression disease BEFREE The mRNA levels of PLA2 VIIA (platelet-activating factor (PAF) acetylhydrolase) were lower in SAR patients than controls, both during pollen season (p = 0.03) and off season (p = 0.03). 15224635 2004
Entrez Id: 7534
Gene Symbol: YWHAZ
YWHAZ
0.010 AlteredExpression disease BEFREE Phospholipase A2 mRNA expression in the nasal mucosa of healthy subjects and patients with seasonal allergic rhinitis. 15224635 2004
Entrez Id: 9768
Gene Symbol: PCLAF
PCLAF
0.010 Biomarker disease BEFREE The observation that PAF acetylhydrolase mRNA expression in the nasal mucosa is lower in SAR patients than in healthy subjects suggests the possibility that impaired ability to inactivate PAF might be of importance in SAR. 15224635 2004
Entrez Id: 151056
Gene Symbol: PLB1
PLB1
0.010 AlteredExpression disease BEFREE Phospholipase A2 mRNA expression in the nasal mucosa of healthy subjects and patients with seasonal allergic rhinitis. 15224635 2004
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.010 GeneticVariation disease BEFREE Our data suggest an association of genetic variants in IL-6 and IL-2 with hayfever, confirm a role of polymorphisms in IL-4R, IL-13, and IL-18 for the elevated IgE phenotype, and add IL-6 to the list of candidate genes. 15005726 2004
Entrez Id: 3269
Gene Symbol: HRH1
HRH1
0.030 AlteredExpression disease BEFREE H1R mRNA was significantly elevated in epithelial (P<0.001) and mucus cells (P<0.05) of PAR in comparison with non-AR whereas H1R gene expression levels in endothelial cells between both groups were not changed (P=0.23). 16297140 2005
Entrez Id: 4283
Gene Symbol: CXCL9
CXCL9
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 GeneticVariation disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 55153
Gene Symbol: SDAD1
SDAD1
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 6373
Gene Symbol: CXCL11
CXCL11
0.010 Biomarker disease BEFREE The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR (P = .001-.04). 15753903 2005
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.030 GeneticVariation disease BEFREE Our data suggest lack of evidence for identifying the variant Arg110Glnat the IL13 locus as a genetic risk factor involved in the development of Japanese cedar pollinosis. 16272823 2006
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.020 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 55065
Gene Symbol: SLC52A1
SLC52A1
0.010 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
0.010 Biomarker disease BEFREE The abundant presence and distribution of gene and protein expression of PAR 2 in different cell types in the nasal mucosa under normal situation, the increased expression of PAR 2 in epithelial cells and the increased number of eosinophils with PAR 2 suggest that PAR 2 may contribute to the pathogenesis of allergic diseases such as SAR. 16911360 2006
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.110 AlteredExpression disease BEFREE There were no significant differences between the rhinitic and non-rhinitic groups in the expression of TGF-beta isoforms or Smad-3, Smad-6 and Smad-7 proteins; however, there was increased gene expression for TGF-betaRI and TGF-betaRII along with CTGF in seasonal allergic rhinitis. 18201469 2007
Entrez Id: 2829
Gene Symbol: XCR1
XCR1
0.010 GeneticVariation disease BEFREE We sequenced CCR1, CCR2, CCR3, CCR5, and CCXCR1 using the PCR restriction fragment length polymorphism method in subjects with cedar pollinosis and controls. 17135764 2007