Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1843
Gene Symbol: DUSP1
DUSP1
0.010 Biomarker disease BEFREE FOS, JUN, and DUSP1 could be used as candidate targets for the treatment of seasonal allergic rhinitis (SAR) during the pollen season, while KLF4 and CD163 could be used as candidate targets outside the pollen season. 26189617 2015
Entrez Id: 5169
Gene Symbol: ENPP3
ENPP3
0.010 AlteredExpression disease BEFREE This study showed that allergen-induced surface CD203c expression on basophils in seasonal allergic rhinitis caused by Japanese cedar pollen exhibited a time-of-day-dependent variation associated with temporal variations in canonical circadian clock gene expression. 25443426 2015
Entrez Id: 28955
Gene Symbol: DEXI
DEXI
0.010 GeneticVariation disease BEFREE The rs62026376:C allele associated with increased asthma with hay fever risk has been found to be associated also with decreased expression of the nearby DEXI gene in monocytes. 24388013 2014
Entrez Id: 2615
Gene Symbol: LRRC32
LRRC32
0.010 GeneticVariation disease BEFREE A variant near LRRC32 was a stronger risk factor for hay fever than for asthma, whereas the reverse was observed for variants in/near GSDMA and TSLP. 24388013 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.010 GeneticVariation disease BEFREE Single nucleotide polymorphisms with suggestive evidence for association with asthma with hay fever risk included rs41295115 near IL2RA (OR, 1.28; P = 5 × 10(-7)) and rs76043829 in TNS1 (OR, 1.23; P = 2 × 10(-6)). 24388013 2014
Entrez Id: 4586
Gene Symbol: MUC5AC
MUC5AC
0.010 GeneticVariation disease BEFREE Statistically significant associations between the 3'ter MUC5AC simple nucleotide polymorphism (SNP) rs1132440 and various non-independent respiratory outcomes (bronchitis, wheeze, asthma, hay fever) were reported while the adjacent loci show slight (but largely non-statistically significant) differences, presumably reflective of linkage disequilibrium (allelic association) across the region. 23551418 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.010 GeneticVariation disease BEFREE The objective of this study was to investigate whether SNPs of the MMP9 gene are associated with risk of seasonal AR (pollinosis), perennial AR and allergen sensitization. 22237587 2012
Entrez Id: 4069
Gene Symbol: LYZ
LYZ
0.010 Biomarker disease BEFREE To develop a treatment for pollen allergy by inducing oral tolerance, we generated genetically manipulated (GM) chickens by retroviral gene transduction, to produce a fusion protein of chicken egg white lysozyme and a peptide derived from seven dominant human T-cell epitopes of Japanese cedar pollen allergens (cLys-7crp). 23144766 2012
Entrez Id: 4012
Gene Symbol: LNPEP
LNPEP
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 1483
Gene Symbol: CTAA1
CTAA1
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 23765
Gene Symbol: IL17RA
IL17RA
0.010 AlteredExpression disease BEFREE Among these 3 genes, the expression of interleukin 17 receptor beta (IL17RB) was confirmed to be upregulated in SAR patients compared to that of the IL17RB gene in healthy, non-allergic controls. 21252617 2011
Entrez Id: 10580
Gene Symbol: SORBS1
SORBS1
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 5269
Gene Symbol: SERPINB6
SERPINB6
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 3126
Gene Symbol: HLA-DRB4
HLA-DRB4
0.010 GeneticVariation disease BEFREE The HLA variant rs7775228, which cis-regulates HLA-DRB4, was strongly associated with grass sensitization and weakly with AR (P(grass) = 1.6 × 10(-9); P(AR) = 8.0 × 10(-3)). 22036096 2011
Entrez Id: 1439
Gene Symbol: CSF2RB
CSF2RB
0.010 GeneticVariation disease BEFREE CSF2RB rs16997517 was directly related to pollen allergies in controls and to reduced SCC risk. 21071541 2011
Entrez Id: 23476
Gene Symbol: BRD4
BRD4
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 10487
Gene Symbol: CAP1
CAP1
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 9200
Gene Symbol: HACD1
HACD1
0.010 Biomarker disease BEFREE Component-based microarray ISAC CRD103 and whole-allergen CAP showed high Se and Sp diagnosing equally grass and cypress pollen allergy. 21749500 2011
Entrez Id: 7356
Gene Symbol: SCGB1A1
SCGB1A1
0.010 GeneticVariation disease BEFREE For CC16 A38G, an interaction was significant for ever rhinitis (P(interaction) = 0.006), rhinitis <12 mo (P(interaction) = 0.004), and marginally significant for ever hayfever (P(interaction) = 0.07), allergic eye symptoms <12 mo (P(interaction) = 0.09); their risk allele was G in Russians and A in Finns. 19222419 2009
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.010 AlteredExpression disease BEFREE Notably, the change of FOXP3 gene expression in donors showing peptide-specific T-helper responses was significantly lower than that in nonresponders, regardless of allergic pollinosis. 19178794 2009
Entrez Id: 6351
Gene Symbol: CCL4
CCL4
0.010 AlteredExpression disease BEFREE Analysis of nasal fluid CCL4 protein confirmed lower levels in women with seasonal allergic rhinitis, before and during the pollen season. 18440239 2008
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.010 AlteredExpression disease LHGDN Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis. 18782112 2008
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
0.010 AlteredExpression disease LHGDN Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis. 18782112 2008
Entrez Id: 3135
Gene Symbol: HLA-G
HLA-G
0.010 AlteredExpression disease LHGDN Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis. 18782112 2008
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.010 AlteredExpression disease LHGDN Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis. 18782112 2008