Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 Biomarker disease BEFREE The overproduction of IP-10 by PnMECs leads to the focal breakdown of the BNB and may help to mediate the transfer of pathogenic T cells across the BNB, thereby resulting in the appearance of conduction block in electrophysiological studies of patients with MADSAM and MMN. 30523038 2019
Entrez Id: 1994
Gene Symbol: ELAVL1
ELAVL1
0.010 Biomarker disease BEFREE Differences between REG and HUA regarded conduction block (CB) and job type. 31369403 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.010 GeneticVariation disease BEFREE Patients with hereditary ATTR amyloidosis occasionally show electrophysiological demyelinating features without conduction block following severe axonal degeneration. 30688105 2019
Entrez Id: 6625
Gene Symbol: SNRNP70
SNRNP70
0.010 Biomarker disease BEFREE While the true frequency of heart block associated with anti-U1RNP remains to be determined, this study might raise the consideration of echocardiographic surveillance in this setting. 31079145 2019
Entrez Id: 9635
Gene Symbol: CLCA2
CLCA2
0.010 GeneticVariation disease BEFREE Our findings indicate that a novel heterozygous missense mutation c.G1725T of the CLCA2 gene may be associated with heart block disease and the mutation in this gene may lead to sinus node lesions and conduction blocking. 31326550 2019
Entrez Id: 3502
Gene Symbol: IGHG3
IGHG3
0.010 Biomarker disease BEFREE Our data suggest that anti-contactin-1 IgG3 induces an acute conduction block that is most probably mediated by autoantibody binding and subsequent complement deposition and may account for acute onset of disease in these patients. 30953561 2019
Entrez Id: 5967
Gene Symbol: REG1A
REG1A
0.010 Biomarker disease BEFREE Differences between REG and HUA regarded conduction block (CB) and job type. 31369403 2019
Entrez Id: 24145
Gene Symbol: PANX1
PANX1
0.010 Biomarker disease BEFREE <b>Background:</b> Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl<sup>-</sup>/HCO<sub>3</sub><sup>-</sup> exchanger, pendrin. 30050451 2018
Entrez Id: 51083
Gene Symbol: GAL
GAL
0.010 Biomarker disease BEFREE Here we report that photostimulation of VLPO<sup>GAL</sup> neurons in mice promotes sleep with low frequency stimulation (1-4 Hz), but causes conduction block and waking at frequencies above 8 Hz. 30297727 2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.010 Biomarker disease BEFREE Collapse in the elderly: rivastigmine-induced heart block and a literature review of the pharmacology of acetylcholinesterase inhibitors used in Alzheimer's disease. 29666099 2018
Entrez Id: 79054
Gene Symbol: TRPM8
TRPM8
0.010 GeneticVariation disease BEFREE These results show that the ability of somatosensory TRP channels to promote the permeation of large cations also includes TRPM8, thereby suggesting that novel approaches to alter cold pain can also be employed via conduction block in TRPM8-positive sensory neurons. 28038937 2017
Entrez Id: 51422
Gene Symbol: PRKAG2
PRKAG2
0.010 GeneticVariation disease BEFREE Mutations in PRKAG2, the gene encoding for the γ2 subunit of 5'-AMP-activated protein kinase (AMPK), are responsible for an autosomal dominant glycogenosis with a cardiac presentation, associating hypertrophic cardiomyopathy (HCM), ventricular pre-excitation (VPE), and progressive heart block. 28431061 2017
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.010 Biomarker disease BEFREE We aimed to evaluate the feasibility of the heart block with electron compensation (HBE) technique, based on three-dimensional conformal radiotherapy (3D-CRT) in left-sided breast cancer patients with underlying cardiac or pulmonary disease. 28863179 2017
Entrez Id: 6535
Gene Symbol: SLC6A8
SLC6A8
0.010 Biomarker disease BEFREE We aimed to evaluate the feasibility of the heart block with electron compensation (HBE) technique, based on three-dimensional conformal radiotherapy (3D-CRT) in left-sided breast cancer patients with underlying cardiac or pulmonary disease. 28863179 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.010 Biomarker disease BEFREE We aimed to evaluate the feasibility of the heart block with electron compensation (HBE) technique, based on three-dimensional conformal radiotherapy (3D-CRT) in left-sided breast cancer patients with underlying cardiac or pulmonary disease. 28863179 2017
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
0.010 Biomarker disease BEFREE Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block. 26432597 2016
Entrez Id: 342035
Gene Symbol: GLDN
GLDN
0.010 Biomarker disease BEFREE Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN. 25283719 2014
Entrez Id: 55998
Gene Symbol: NXF5
NXF5
0.010 GeneticVariation disease BEFREE Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene. 23686279 2013
Entrez Id: 4359
Gene Symbol: MPZ
MPZ
0.010 GeneticVariation disease BEFREE This case highlights that patchy demyelinating neuropathy with conduction block may occur in p.Ile112Thr MPZ mutations. 21256749 2011
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 GeneticVariation disease BEFREE The ACE I/D polymorphism was associated with the PR interval and heart block in the lone AF cohort. 19648063 2009
Entrez Id: 1959
Gene Symbol: EGR2
EGR2
0.010 Biomarker disease BEFREE These studies describe a unique animal model of CMT, whereby weakness is due to conduction block or neuromuscular junction failure rather than secondary axon loss and demonstrate that the Egr2-Nab complex is critical for proper peripheral nerve myelination. 19244508 2009
Entrez Id: 93649
Gene Symbol: MYOCD
MYOCD
0.010 AlteredExpression disease BEFREE Forced myocardin expression also endowed human MSFs with the ability to transmit an action potential and to repair an artificially created conduction block in cardiomyocyte cultures. 17579192 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.010 Biomarker disease LHGDN Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block. 12960355 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 GeneticVariation disease LHGDN Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block. 12960355 2003
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.010 GeneticVariation disease BEFREE We present clinical, genetic, and biophysical features of 2 new SCN5A mutations that result in atrioventricular (AV) conduction block. 11804990 2002