Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 GeneticVariation disease BEFREE The ACE I/D polymorphism was associated with the PR interval and heart block in the lone AF cohort. 19648063 2009
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.010 Biomarker disease BEFREE Collapse in the elderly: rivastigmine-induced heart block and a literature review of the pharmacology of acetylcholinesterase inhibitors used in Alzheimer's disease. 29666099 2018
Entrez Id: 56244
Gene Symbol: BTNL2
BTNL2
0.100 Biomarker disease HPO
Entrez Id: 776
Gene Symbol: CACNA1D
CACNA1D
0.300 Biomarker disease CTD_human G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. 26831068 2016
Entrez Id: 799
Gene Symbol: CALCR
CALCR
0.010 Biomarker disease BEFREE We aimed to evaluate the feasibility of the heart block with electron compensation (HBE) technique, based on three-dimensional conformal radiotherapy (3D-CRT) in left-sided breast cancer patients with underlying cardiac or pulmonary disease. 28863179 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.010 Biomarker disease BEFREE We aimed to evaluate the feasibility of the heart block with electron compensation (HBE) technique, based on three-dimensional conformal radiotherapy (3D-CRT) in left-sided breast cancer patients with underlying cardiac or pulmonary disease. 28863179 2017
Entrez Id: 822
Gene Symbol: CAPG
CAPG
0.010 AlteredExpression disease BEFREE To examine fetal characteristics which might influence autoantibody-mediated diseases acquired in utero, such as heart block in neonatal lupus, the tissue expression of MCP was studied. 8528226 1995
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.010 AlteredExpression disease BEFREE To examine fetal characteristics which might influence autoantibody-mediated diseases acquired in utero, such as heart block in neonatal lupus, the tissue expression of MCP was studied. 8528226 1995
Entrez Id: 9635
Gene Symbol: CLCA2
CLCA2
0.010 GeneticVariation disease BEFREE Our findings indicate that a novel heterozygous missense mutation c.G1725T of the CLCA2 gene may be associated with heart block disease and the mutation in this gene may lead to sinus node lesions and conduction blocking. 31326550 2019
Entrez Id: 4512
Gene Symbol: COX1
COX1
0.100 Biomarker disease HPO
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.100 Biomarker disease HPO
Entrez Id: 4514
Gene Symbol: COX3
COX3
0.100 Biomarker disease HPO
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
0.010 Biomarker disease BEFREE The overproduction of IP-10 by PnMECs leads to the focal breakdown of the BNB and may help to mediate the transfer of pathogenic T cells across the BNB, thereby resulting in the appearance of conduction block in electrophysiological studies of patients with MADSAM and MMN. 30523038 2019
Entrez Id: 1674
Gene Symbol: DES
DES
0.020 GeneticVariation disease BEFREE Desmin myopathy is a familial or sporadic disorder characterized by the presence of desmin mutations that cause skeletal muscle weakness associated with cardiac conduction block, arrhythmia and heart failure. 12609507 2003
Entrez Id: 1674
Gene Symbol: DES
DES
0.020 GeneticVariation disease BEFREE Characterization of a novel S13F desmin mutation associated with desmin myopathy and heart block in a Chinese family. 18061454 2008
Entrez Id: 1959
Gene Symbol: EGR2
EGR2
0.010 Biomarker disease BEFREE These studies describe a unique animal model of CMT, whereby weakness is due to conduction block or neuromuscular junction failure rather than secondary axon loss and demonstrate that the Egr2-Nab complex is critical for proper peripheral nerve myelination. 19244508 2009
Entrez Id: 1994
Gene Symbol: ELAVL1
ELAVL1
0.010 Biomarker disease BEFREE Differences between REG and HUA regarded conduction block (CB) and job type. 31369403 2019
Entrez Id: 2010
Gene Symbol: EMD
EMD
0.010 GeneticVariation disease BEFREE Emery-Dreifuss Muscular Dystrophy (EMD or EDMD) is a rare X-linked recessive disorder, characterized by progressive muscle wasting and weakness, contractures, and cardiomyopathy, manifesting as heart block. 11385714 2001
Entrez Id: 51083
Gene Symbol: GAL
GAL
0.010 Biomarker disease BEFREE Here we report that photostimulation of VLPO<sup>GAL</sup> neurons in mice promotes sleep with low frequency stimulation (1-4 Hz), but causes conduction block and waking at frequencies above 8 Hz. 30297727 2018
Entrez Id: 342035
Gene Symbol: GLDN
GLDN
0.010 Biomarker disease BEFREE Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN. 25283719 2014
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease HPO
Entrez Id: 3502
Gene Symbol: IGHG3
IGHG3
0.010 Biomarker disease BEFREE Our data suggest that anti-contactin-1 IgG3 induces an acute conduction block that is most probably mediated by autoantibody binding and subsequent complement deposition and may account for acute onset of disease in these patients. 30953561 2019
Entrez Id: 3762
Gene Symbol: KCNJ5
KCNJ5
0.300 Therapeutic disease CTD_human G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block. 26831068 2016
Entrez Id: 11155
Gene Symbol: LDB3
LDB3
0.100 Biomarker disease HPO
Entrez Id: 4000
Gene Symbol: LMNA
LMNA
0.330 GeneticVariation disease BEFREE A missense mutation in the exon 8 of lamin A/C gene in a Japanese case of autosomal dominant limb-girdle muscular dystrophy and cardiac conduction block. 11525883 2001