Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25893
Gene Symbol: TRIM58
0.010 Biomarker disease BEFREE In addition, we found a significant decrease in the growth and weight of tumors and an increase in tumor cell apoptosis in TRIM58-overexpression nude mice, which were also accompanied by reduced β-catenin expression.<b>Conclusions</b>: These data suggest that TRIM58 may function as a tumor suppressor in GC and potentially suppress the tumor growth of gastric cancer by inactivation of β-catenin signaling via ubiquitination. 31747856 2020
Entrez Id: 80144
Gene Symbol: FRAS1
0.010 Biomarker disease BEFREE We concluded that FRAS1 contributes to the malignant phenotype of GC, especially liver metastasis, and may therefore serve as a predictive marker or a target for treating liver metastasis. 31597194 2020
Entrez Id: 5754
Gene Symbol: PTK7
0.010 AlteredExpression disease BEFREE PTK-7 Expression in Gastric Cancer: A Prognostic Determinant 31820857 2020
Entrez Id: 6749
Gene Symbol: SSRP1
0.010 AlteredExpression disease BEFREE Although abnormal HMGB expression is associated with various tumors, the relationship with gastric cancer (GC) remains unclear. 31621076 2020
Entrez Id: 9173
Gene Symbol: IL1RL1
0.010 AlteredExpression disease BEFREE In this study, we find that IL-33 and its receptor ST2L are upregulated in the human GC and served as prognostic markers for poor survival of GC patients. 31659258 2020
Entrez Id: 590
Gene Symbol: BCHE
0.010 AlteredExpression disease BEFREE Our study showed that adjuvant chemotherapy with S-1 and high level of serum cholinesterase were considered as the risk factors for NAFLD occurring after gastrectomy for gastric cancer. 31555950 2020
Entrez Id: 56651
Gene Symbol: LINC00470
0.010 Biomarker disease BEFREE However, the clinical significance and functional role of LINC00470 in the progression of GC is largely unknown. 31711642 2020
Entrez Id: 55273
Gene Symbol: TMEM100
0.010 AlteredExpression disease BEFREE Additionally, TMEM100 expression restored the sensitivity of GC cells to chemotherapeutic drugs such as 5-fluouracil (5-FU) and cisplatin. 31188741 2020
Entrez Id: 11060
Gene Symbol: WWP2
0.010 Biomarker disease BEFREE Using a WWP2-shRNA lentivirus expressing system, we established WWP2 stable-knockdown GC cell lines and found that knockdown of WWP2 inhibits the proliferation of GC cells both in vitro and in vivo. 31677789 2020
Entrez Id: 2776
Gene Symbol: GNAQ
0.010 AlteredExpression disease BEFREE Furthermore, we analyzed the potential relationship between serum exosomal lnc-GNAQ-6:1 expression and clinicopathological parameters of gastric cancer. 31730812 2020
Entrez Id: 1434
Gene Symbol: CSE1L
0.010 AlteredExpression disease BEFREE Taken together, our study revealed that CSE1L inhibition decreased MITF and suppressed GPNMB expression, thereby activating the PI3K/Akt/mTOR and MEK/ERK signaling pathway, ultimately inhibiting the tumor growth and metastasis in GC. 31347172 2020
Entrez Id: 100996609
Gene Symbol: LINC01436
0.010 Biomarker disease BEFREE Collectively, these results suggested that LINC01436 was an oncogenic lncRNA in GC and promoted proliferation and metastasis of GC cell via regulating miR-585 and FBOX11.This article is protected by copyright.All rights reserved. 31829474 2020
Entrez Id: 11184
Gene Symbol: MAP4K1
0.010 AlteredExpression disease BEFREE Moreover, MAP4K1 down-regulation similarly inhibited GC progression. 31591939 2020
Entrez Id: 100505881
Gene Symbol: MAGI2-AS3
0.010 AlteredExpression disease BEFREE First, bioinformatics analysis showed that lncRNA MAGI2-AS3 was overexpressed in gastric cancer tissues, and the overexpression of MAGI2-AS3 has been shown to be associated with poor prognosis in all three independent gastric cancer cohorts (The Cancer Genome Atlas stomach cancer [TCGA_STAD], GEO: GSE62254 and GSE15459). 31837602 2020
Entrez Id: 5451
Gene Symbol: POU2F1
0.010 Biomarker disease BEFREE The function of the DLX6-AS1/miR-204-5p/OCT1 axis in GC proliferation was clarified by rescue assays. 31463827 2020
Entrez Id: 10457
Gene Symbol: GPNMB
0.010 Biomarker disease BEFREE In addition, GPNMB may augment the immunosuppressive ability of gastric cancer by recruiting immunosuppressive cells and promoting immune cell exhaustion through PI3K/AKT/CCL4 signaling axis. 31498430 2020
Entrez Id: 5905
Gene Symbol: RANGAP1
0.010 Biomarker disease BEFREE Additionally, circ-RanGAP1 silencing remarkably suppressed tumor growth and metastasis of GC in vivo. 31811909 2020
Entrez Id: 100302142
Gene Symbol: MIR1246
0.010 Biomarker disease BEFREE Circulating exosomal miR-1246 was a potential biomarker for the early diagnosis of GC. 31506750 2020
Entrez Id: 60312
Gene Symbol: AFAP1
0.010 AlteredExpression disease BEFREE Growing evidence indicates that two long non-coding RNAs (lncRNAs), FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) and Actin filament associated protein 1 antisenseRNA1 (AFAP1-AS1), are highly expressed in different cancers, including gastric cancer (GC). 31785996 2020
Entrez Id: 101928483
Gene Symbol: NALT1
0.010 AlteredExpression disease BEFREE NALT1 is overexpressed and promotes invasion and metastasis of GC. 31802831 2019
Entrez Id: 7133
Gene Symbol: TNFRSF1B
0.010 Biomarker disease BEFREE Up-regulation of tumor necrosis factor-α pathway survival genes and of the receptor TNFR2 in gastric cancer. 31040894 2019
Entrez Id: 282616
Gene Symbol: IFNL2
0.010 AlteredExpression disease BEFREE LEGENDplex bead-based immunoassays were used to analyze the serum IFN-α, IFN-β, IFN-γ, IFN-λ1, and IFN-λ2/3 levels in patients with GC and healthy volunteers. 30672717 2019
Entrez Id: 80380
Gene Symbol: PDCD1LG2
0.010 Biomarker disease BEFREE While the incidence and mortality of gastric cancer (GC) remains high, and prognosis of GC remains poor, molecules in programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), and programmed death-ligand 2 (PD-L2) pathway are promising prognostic biomarker of GC. 30353572 2019
Entrez Id: 940
Gene Symbol: CD28
0.010 Biomarker disease BEFREE We verified MSLN expression in primary human GC tissues and GC cell lines and then redirected T cells with a CAR containing the MSLN scFv (single-chain variable fragment), CD3ζ, CD28, and DAP10 intracellular signaling domain (M28z10) to target MSLN. 30777106 2019
Entrez Id: 57446
Gene Symbol: NDRG3
0.010 Biomarker disease BEFREE In conclusion, the results of the present study suggest that the SNHG20/miR-140-5p/NDRG3 axis may be involved in mediating resistance to 5-FU in gastric cancer. 31423195 2019