Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet. 22102511 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE We further show that in the context of diet-induced obesity PPARγ-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity that typically accompanies PPARγ activation by TZDs. 30420515 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity. 24969838 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease UNIPROT Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. 9753710 1998
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR. 15860437 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Importantly, the results of the analysis of gene-diet interactions suggest that the allelic variants of candidate genes (leptin, TNFA, PPARG2) might strongly affect diet-related obesity risk. 12395215 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity. 19913841 2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome. 21643757 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association. 22410809 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity. 15972940 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034). 24200052 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE This finding suggests that the PPARG gene has a gender-specific effect and contributes to the susceptibility to obesity in this population. 17653445 2007
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Peroxisome proliferator-activated receptor gamma is an important regulator of adiposity in mouse and man, and common variation in the PPARG gene has been associated with birthweight, adult obesity, insulin sensitivity and type 2 diabetes. 16007414 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. 11916956 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Genetic polymorphisms in peroxisome proliferator-activated receptor gamma are associated with Type 2 diabetes mellitus and obesity in the Korean population. 16108843 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment. 17052804 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The rs1801282;rs1805192" genes_norm="5468">Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity. 18280041 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Potential interactions between prenatal DHA and the peroxisome proliferator-activated receptor-γ (PPARγ) genotype as a measure of the genetic predisposition to obesity were investigated. 27030533 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Mutations in the PPARgamma gene are unlikely to be major contributors to HAIRAN syndrome with obesity. 10762291 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE In 1708 women of the EDEN mother-child cohort, the PPARγ Pro12Ala and C1431T polymorphisms were genotyped and analyzed in association with maternal prepregnancy body mass index, obesity before pregnancy, and gestational diabetes, separately and also combined in haplotypes. 21795447 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Here, we show that targeted PPARγ mutations resulting in constitutive deacetylation (K268R/K293R, 2KR) increased energy expenditure and protected from visceral adiposity and diet-induced obesity by augmenting brown remodeling of white adipose tissues. 29589839 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. 19733160 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m2) nondiabetic subjects. 16231017 2006
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis. 19766907 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005). 16029943 2005