Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet. 22102511 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Understanding the role natural products play, as well as the mechanisms behind their regulation of PPARγ activity is critical for future research into their therapeutic potential for fighting obesity. 27669202 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE We further show that in the context of diet-induced obesity PPARγ-K107R-mutant mice have enhanced insulin sensitivity without the corresponding increase in adiposity that typically accompanies PPARγ activation by TZDs. 30420515 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE This modification of PPARgamma does not alter its adipogenic capacity, but leads to dysregulation of a large number of genes whose expression is altered in obesity, including a reduction in the expression of the insulin-sensitizing adipokine, adiponectin. 20651683 2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. 11574398 2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE This review highlights the roles that PPARgamma play in the regulation of gene expression associated with normal cell physiology as well as the pathophysiology of multiple diseases including obesity, diabetes and cancer. 11900961 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The fat mass and obesity-associated gene (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma 2 gene (PPARG2) rs1801282 polymorphisms are type 2 diabetes mellitus susceptibility gene variants associated with obesity. 24969838 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Furthermore, the P12A PPARgamma polymorphism was not associated with obesity or WHR in the control population; it did not interact with energy intake or energy expenditure to alter risk of obesity or large WHR. 15860437 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Importantly, the results of the analysis of gene-diet interactions suggest that the allelic variants of candidate genes (leptin, TNFA, PPARG2) might strongly affect diet-related obesity risk. 12395215 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE <i>PPARG-LYPLAL1</i> Multi-Allelic Combination Associated with Obesity and Overweight in Mexican Adolescent Females. 27773974 2016
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Peroxisome Proliferator-Activated Receptor Gamma in Obesity and Colorectal Cancer: the Role of Epigenetics. 28878369 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha gene is associated with oxidative stress and abdominal obesity. 19913841 2010
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity. 18657264 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Phtalates are thought to contribute to obesity through their binding and activation of PPARγ receptor that in turn results in the upregulation of adipocyte production. 27358237 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin. 15725703 2005
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE PPARG mRNA expression decreased 32% (P = 0.044) in adipocytes from individuals with obesity. 31531958 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) regulates adipocyte differentiation and lipid deposition, but its role in lipolysis and dysregulation in obesity is not well defined. 22310664 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE We identified PPARγ as a potential target of Twist 1 and found variation in the secretion of multiple adipokines, which might indicate a prospective mechanism linking Twist 1 expression with obesity or associated diseases. 25128964 2014
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Moreover, we elucidated the molecular mechanisms and transcription factors causing the SHBG down-regulation during obesity development, which involved changes in liver hepatocyte nuclear factor 4α and peroxisome proliferator-activated receptor-γ mRNA and protein levels. 26441241 2015
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome. 21643757 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Our results suggest that a novel MG derivative, CBMG may have beneficial applications in the control of obesity through the suppression of PPARγ-induced adipocyte differentiation and lipid accumulation. 28625492 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE The causes of obesity are multifactorial but may include dysregulation of a family of related genes, such as the peroxisome proliferator activated receptor gamma (PPARgamma). 18855061 2009
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association. 22410809 2012
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Identification of the factors that regulate PPARγ expression and activity is therefore crucial for combating obesity. 31653699 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Some polymorphic genes involved in the regulation of leptin-the leptin gene (LEP A19G), the leptin receptor gene (LEPR Q223R, K109R, and K656N), and the peroxisome proliferator-activated receptor-gamma gene (PPARG P12A and C161T)--have been investigated as possible factors associated with obesity. 15972940 2005