Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease HPO
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects. 9200661 1997
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Finally peroxisome proliferator activated receptor-gamma (PPAR-gamma) mRNA levels were significantly lower in visceral adipose tissue in subjects with a BMI <30 kg/m2, but not in obese subjects, indicating that relative PPAR-gamma expression is increased in omental fat in obesity. 9421381 1998
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Screening for mutations in the entire coding region of the PPAR gamma gene (both gamma 1 and gamma 2 isoforms) was performed with DNA of 26 diabetic Caucasians with or without obesity. 9425261 1997
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE The observation that thiazolidinediones enhance skeletal muscle insulin sensitivity in obesity and in patients with non-insulin-dependent diabetes mellitus (NIDDM), by activating PPARgamma, and possibly by inducing its expression, suggests that PPARgamma expression in skeletal muscle plays a key role in determining tissue sensitivity to insulin, and that PPARgamma expression may be decreased in insulin resistant subjects. 9449686 1998
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease UNIPROT Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. 9753710 1998
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Our results establish a role for PPARgamma in the regulation of EC gene expression, with important implications for the clinical links between obesity and atherosclerosis. 10073956 1999
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Peroxisome proliferator-activated receptor gamma (PPAR gamma) as a transcription factor plays an important role in lipid metabolism, glucose homeostasis, insulin sensitivity, obesity, diabetes, foam cell formation and atherogenesis. 10690291 1999
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Mutations in the PPARgamma gene are unlikely to be major contributors to HAIRAN syndrome with obesity. 10762291 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects. 10843155 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose. 10873398 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Obesity can occur as a result of genetic or acquired changes in three main types of biochemical processes, which are the main focus of this review: a)feeding control, which determines the sensations of satiety and hunger through processes that depend on an interplay between internal signals (notably leptin) and environmental factors; b) energy efficiency, in particular the activation of thermogenesis mediated by uncoupling proteins (UCPs) that makes it possible to dissipate part of the energy contained in food as heat instead of accumulating it as fat, and c) adipogenesis, the process by which cells specialised in fat storage (adipocytes) are formed, which is controlled by an interplay of transcription factors, including members of the C/EBP, PPARgamma and ADD families. 11079733 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease CTD_human Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. 11089532 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds. 11158005 2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE This study reveals a hitherto unpredicted role for PPARgamma in high-fat diet-induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPARgamma. 11242476 2000
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity. 11248748 2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE These observations lend genetic evidence consistent with our hypothesis that PPARG serves as a common, low-penetrance susceptibility gene for cancers of several types, especially those epidemiologically associated with obesity and fat intake. 11511919 2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. 11574398 2001
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. 11832353 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE This study reveals a hitherto unpredicted role for PPARgamma in high-fat diet-induced obesity due to adipocyte hypertrophy and insulin resistance, which requires both alleles of PPARgamma. 11872365 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE This review highlights the roles that PPARgamma play in the regulation of gene expression associated with normal cell physiology as well as the pathophysiology of multiple diseases including obesity, diabetes and cancer. 11900961 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. 11916956 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Importantly, the results of the analysis of gene-diet interactions suggest that the allelic variants of candidate genes (leptin, TNFA, PPARG2) might strongly affect diet-related obesity risk. 12395215 2002
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia. 12406034 2002