Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Obesity could also affect the rate of progression through puberty as nutrition and SHBG may act respectively as an accelerator and brake on peripheral sex steroid action. 16824679 2006
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE Although SHBG SNPs associated with type 2 diabetes mellitus do not appear to be associated with PCOS status, rs1799941 and rs727428 genotypes are associated with SHBG levels independent of the effects of insulin resistance and obesity. 21252242 2011
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Future research using this unique mouse model will determine the role of SHBG in the development and progression of obesity, type 2 diabetes, or fatty liver disease. 26441241 2015
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE Moreover, ICAM1 K469E interacted with obesity and PCOS on serum triglyceride levels (P=0.019) and with PCOS on serum sex hormone-binding globulin concentrations (P=0.006). 26498675 2016
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE The aim of this study was to determine the relationship between SHBG and arterial stiffness in association with central obesity in women. 29213285 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 AlteredExpression disease BEFREE HtgW phenotype distinguishes itself from the (virtually neutral) simple abdominal obesity in independently conferring high CHD risk when elevated or reduced SHBG levels interact. 27846754 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 AlteredExpression disease BEFREE Associations of SHBG with some anthropometric and metabolic variables in FDR suggests that lower levels is a marker for risk of developing T2D through obesity dependent metabolic pathways but low FAI is a better marker of state of diabetes in males. 28950181 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 AlteredExpression disease BEFREE Metabolic component specific analysis showed that sex hormones were inversely associated with several components of MetS: TT with abdominal obesity, low high-density lipoprotein cholesterol (HDL-C) and high blood pressure; cFT with abdominal obesity and high blood pressure; SHBG with all components except high blood pressure. 28581026 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Significant additive interactions with obesity or central obesity were detected for total testosterone (RERI=2.75, 95% CI=0.92,4.59), SHBG (RERI=5.71, 95% CI=0.77,10.64), and FEI (RERI=-9.96, 95% CI=-19.18,-0.74) with regard to IR, beta-cell dysfunction, and T2D. 27914732 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Significant differences in SHBG were observed within the obesity status and gender, with discordant patterns of change in testosterone and estradiol. 28077498 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE Familial presence of hypertension and/or obesity was significantly associated with SBP among adolescent females but not males. 28633388 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 AlteredExpression disease BEFREE This is of importance because reduction of SHBG plasma levels in obese and type 2 diabetic subjects could be directly associated with NAFLD development through an increase in hepatic lipogenesis. 28359088 2017
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. 29752333 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE Also in multivariate logistic regression model, for each increase of a child in the family the risk of abdominal obesity [OR: 0.95; 95% CI: 0.91-0.97), high SBP [OR: 0.88; 95% CI: 0.81-0.95)] and generalized obesity [OR: 0.95; 95% CI: 0.91-0.99)] decreased significantly. 29866072 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE HFD induced comparable obesity in control and <i>SHBG+</i> mice. 29141991 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated. 29770358 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Interest in SHBG has escalated in recent years because of its inverse association with polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, and diabetes type II. 29227165 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI). 29474646 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 AlteredExpression disease BEFREE According to reduced sex hormone-binding globulin levels and increased free androgen index in the present study, obesity was linked with hyperandrogenism in female subjects. 30232779 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE While low circulating total testosterone concentrations in modest obesity primarily reflect reduced concentrations of sex hormone binding globulin, more marked obesity can lead to genuine hypothalamic-pituitary-testicular axis (HPT) suppression. 29683196 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE SHBG is decreased in pregnant women with pregestational plus gestational obesity in association with common cardio-metabolic parameters. 30321217 2018
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Population mean levels show a mild total T decline, an SHBG increase, a steeper free T decline, and a moderate LH increase with important contribution of comorbidities (e.g., obesity) to these changes. 30888401 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE In a multivariate logistic regression analysis, lower peak SBP [odds ratio (OR) 1.02;95% confidence interval (CI) 1.00-1.04, P = 0.017] and rapid early rise in heart rate (OR 15.03; 95% CI 6.23-36.24, P < 0.001) were associated with a higher risk of revealed symptoms while the use of antihypertensive treatment was associated with a lower risk of revealed symptoms (OR 0.40; 95% CI 0.18-0.89, P = 0.025), independent of age, obesity, LV ejection fraction and aortic valve area. 31157741 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 Biomarker disease BEFREE Both boys and girls with obesity had lower sex hormone-binding globulin (SHBG; P < 0.0001) than NW. 30985874 2019
Entrez Id: 6462
Gene Symbol: SHBG
SHBG
0.100 GeneticVariation disease BEFREE Men with obesity often present with low testosterone (T) and sex hormone-binding globulin (SHBG) levels. 31274482 2019