Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Role of peroxisome proliferator-activated receptor-gamma activation on visfatin, advanced glycation end products, and renal oxidative stress in obesity-induced type 2 diabetes mellitus. 29441829 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ. 29770757 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE We developed and tested a novel dual modulator, RB394, which acts as a soluble epoxide hydrolase (sEH) inhibitor and a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist in rat models of the metabolic syndrome-the obese spontaneously hypertensive (SHROB) rat and the obese diabetic Zucker fatty/spontaneously hypertensive heart failure F1 hybrid (ZSF1) rat. 30032428 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Hypocaloric diet reduces UCP3 expression in individuals with obesity and the UCP3, PLIN1 and PPARG2 expression correlate positively with carbohydrate oxidation and negatively with lipid oxidation. 28651828 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Indeed, altered PPARγ transcriptional activity contributes to metabolic syndromes (obesity and hyperglycemia associated with type 2 diabetes mellitus), stroke and neurodegenerative diseases. 29964054 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Rosiglitazone (ROSI), a member of thiazolidinediones (TZDs) which act as high-affinity agonists of the nuclear receptor peroxisome-proliferator-activated receptor-γ (PPARγ), is clinically used as an antidiabetic drug which could attenuate the insulin resistance associated with obesity, hypertension, and impaired glucose tolerance in humans. 30278161 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPARγ), and insulin receptor substrate-1 (IRS-1) are associated with obesity, insulin resistance, and inflammation. 29256014 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE In a Mexican population characterized by high-fat consumption, we hypothesized that the Pro12Ala PPARγ genotype is related to obesity and this relationship is modulated by intake of saturated fatty acids (SFAs) and trans-fatty acids (TFAs). 30122193 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE The obesity suppression was associated with reductions in expression of adipogenic proteins, such as C/EBPα and PPARγ, increases in expression of lipolytic enzymes, such as adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), in WAT of HFD-fed mice. 30463291 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE This review suggests that Hcy contributes to pyroptosis, changes gut microbiome, and alters PPARγ-dependent mechanism(s) via Zfp407-mediated upregulated adipogenesis and misbalanced fatty acid metabolism, which can predispose to obesity and, consequently, obesity-related metabolic disorders. 29890083 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR-γ and Inducing Adipose Tissue Remodeling in Diet-Induced Obese Mice. 29508519 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE The aim of this study was to evaluate ANGPTL4 plasma levels and PPARγ gene expression in peripheral blood mononuclear cells (PBMCs) of children and adolescents with obesity and their association with metabolic parameters. 28733963 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline. 29383825 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE We tested whether a targeted reduction in hepatic peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), which has been shown to occur with obesity, had a negative impact on the metabolic effects of FGF21. 29215172 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE The aim of this study was to investigate the association of selected single nucleotide polymorphisms (SNPs) of cluster of differentiation 36 (CD36) and peroxisome proliferator-activated receptor γ (PPARγ) with VPA-induced weight gain and obesity in epileptic patients. 29984389 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Peroxisome Proliferator-Activated Receptor Gamma in Obesity and Colorectal Cancer: the Role of Epigenetics. 28878369 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Phtalates are thought to contribute to obesity through their binding and activation of PPARγ receptor that in turn results in the upregulation of adipocyte production. 27358237 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Our results suggest that a novel MG derivative, CBMG may have beneficial applications in the control of obesity through the suppression of PPARγ-induced adipocyte differentiation and lipid accumulation. 28625492 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Furthermore, the transcript and protein levels of transcriptional coactivator peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) and estrogen-related receptor-α (ERRα) in DIO-R mice were significantly up-regulated compared with the DIO mice. 28444662 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE In summary, our results show that neuronal PPARγ is required for optimal female fertility but is also involved in the adverse effects of diet-induced obesity by creating leptin resistance potentially through induction of the repressor Socs3. 27841948 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE Although the mechanisms are still not completely understood, prebiotics, probiotics, polyphenols, peroxisome proliferator-activated receptor-γ agonists (such as rosiglitazone) and exercise have been shown to reverse HFD-induced intestinal phenotype and to attenuate the severity of obesity and its associated metabolic complications. 28571979 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE It is well-documented that CL316,243 (a β3 agonist) or rosiglitazone (a PPARγ agonist) can induce white adipocyte populations to brown-like adipocytes, thus increasing energy consumption and combating obesity. 28481288 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 Biomarker disease BEFREE DBZ is a putative PPARγ agonist that prevents HFD-induced obesity-related metabolic syndrome and reverse gut dysbiosis. 28736228 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 GeneticVariation disease BEFREE Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population. 28123453 2017
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
1.000 AlteredExpression disease BEFREE Down-regulation of vascular PPAR-γ contributes to endothelial dysfunction in high-fat diet-induced obese mice exposed to chronic intermittent hypoxia. 28822761 2017