Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE A considerable number of studies have shown that plasma concentrations of FABP4 is increased in obesity and T2DM, and that circulating FABP4 levels are correlated with certain clinical parameters, such as body mass index, insulin resistance, and dyslipidemia. 30857223 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Pharmacological modification of FABP4 function by specific inhibitors, neutralizing antibodies or antagonists of unidentified receptors would be novel therapeutic strategies for several diseases, including obesity, diabetes mellitus, atherosclerosis and cardiovascular disease. 30726793 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE In this study, we investigated the effects of HFD on obesity and insulin resistance in two distinct types of adipose-specific L-PGDS gene knockout (KO) mice: fatty acid binding protein 4 (fabp4, aP2)-Cre/L-PGDS <sup>flox/flox</sup> and adiponectin (AdipoQ)-Cre/L-PGDS <sup>flox/flox</sup> mice. 30760783 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Serum adipocyte fatty acid-binding protein (A-FABP) is closely correlated to metabolic disorders such as obesity and insulin resistance (IR). 30554468 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE However, chronic engagement of FABP4 under conditions of immunometabolic stress, such as obesity, exacerbates a number of immunometabolic diseases, including diabetes, asthma, cancer, and atherosclerosis. 30705117 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE In the subgroup of women combined with obesity and FABP4 ≥median, the measured OR was 9.83 (95% CI [4.76-16.13]; p < 0.001) for GDM compared to those without obesity and FABP4 <median. 30428456 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 GeneticVariation disease BEFREE Transgenic (Tg) mouse models overexpressing PHB (PHB-Tg) and a phospho-mutant PHB (mPHB-Tg) from the fatty acid binding protein-4 (Fabp-4) gene promoter display sex-neutral obesity; however, obesity-related insulin resistance and metabolic dysregulation are male-specific. 31118075 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Fatty acid-binding protein-4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. 31025416 2019
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Fatty acid binding protein 4 (FABP4) is a novel adipokine that is closely associated with obesity and metabolic diseases. 29549054 2018
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE These data suggest FABP4, an FABP not normally expressed in the liver, can be synthesized and secreted by hepatocytes and HCC cells, and that FABP4 may play a role in regulating tumour progression in the underlying setting of obesity. 29171144 2018
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 AlteredExpression disease BEFREE FABP4 is secreted from adipocytes in association with lipolysis, and an elevated circulating FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. 28903937 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Loss of FABP4 in peripheral macrophages via either molecular or pharmacologic mechanisms results in reduced obesity-induced inflammation via a UCP2-redox based mechanism. 28214555 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE AFABP may also be involved in fetal growth and the association between SGA status and obesity and metabolic syndrome in later life. 28324040 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Taken together, FABP4 may enhance PCa progression and invasiveness by upregulating matrix metalloproteinases and cytokine production in the PCa stromal microenvironment, especially under HFD or obesity. 29340091 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 GeneticVariation disease BEFREE Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via upregulation of the uncoupling protein 2 (UCP2). 27795298 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE A-FABP-JAK2 axis may represent an important pathological pathway contributing to obesity-related inflammatory diseases. 28094778 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE Our findings reveal the FABP4/DNMT1 axis in the control of AML cell fate in obesity and suggest that interference with the FABP4/DNMT1 axis might be a new strategy to treat leukemia. 27885273 2017
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 AlteredExpression disease BEFREE Increased circulating FABP4 level is associated with obesity, insulin resistance and atherosclerosis. 26754658 2016
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 GeneticVariation disease BEFREE The aim of this study is to evaluate the impact of FABP4 polymorphisms on FABP4 plasma levels and subclinical arteriosclerosis in patients with obesity, metabolic syndrome (MS) or type 2 diabetes (T2DM). 26141940 2015
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE We generated the aP2-promoter driven Timm44 transgenic (Tg) mouse model and investigated whether Timm44 Tg mice fed high-fat/high-sucrose (HFHS) chow are protected from type 2 diabetes and obesity. 25749183 2015
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE fabp4 is central to eight obesity associated genes: a functional gene network-based polymorphic study. 25280936 2015
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 AlteredExpression disease BEFREE Although none of these activities was significantly different between the obese and normal-weight children, lactonase activity was found to be positively correlated with HDL-cholesterol and ApoA1 levels and negatively correlated with myeloperoxidase and fatty acid-binding protein 4 levels. 23789921 2013
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 GeneticVariation disease BEFREE The association study showed a significant positive association of the promoter variant -844A/G with childhood obesity and biomarkers of obesity such as weight, body mass index (BMI), BMI Z-Score, and adipocyte fatty acid-binding protein, along with a tendency toward significance with insulin resistance biomarkers. 23641975 2013
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 AlteredExpression disease BEFREE In obesity FABP4 expression was down-regulated (at both mRNA and protein levels), with its levels mainly predicted by ATGL and inversely by the HOMA-IR index. 23139800 2012
Entrez Id: 2167
Gene Symbol: FABP4
FABP4
0.100 Biomarker disease BEFREE The aims of this study were to assess the relationship between FABP4 and inflammatory cytokines related to obesity, and to evaluate FABP4 mRNA expression in visceral and subcutaneous adipose tissue in non-diabetic morbidly obese women versus healthy lean women. 21257725 2011