Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Adipokine chemerin was known for its relationship with obesity as well as metabolism. 31781638 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE In humans, chemerin is positively associated with blood pressure and obesity so we hypothesized that in a model of hypertension derived from high-fat (HF) feeding, the chemerin ASO would reduce blood pressure more than a high-salt (HS) model. 31588871 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Collectively, chemerin, factors associated with obesity, pathological and physiological changes in glucolipid metabolism, and inflammatory factors may promote the development of T2DM macroangiopathy. 31078135 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease RGD To evaluate the effects of probiotic supplementation on chemerin level, inflammation, and metabolic syndrome components in obese Wistar rats. 31284705 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Chemerin Isoforms and Activity in Obesity. 30841637 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 AlteredExpression disease BEFREE In the CAD population, borderline significance was noted between <i>RARRES2</i> polymorphisms and chemerin levels, whereas high chemerin levels were associated with obesity, female sex, diabetes mellitus, hypertension, current smoking, high platelet and leukocyte counts, anemia, impaired renal function, high C-reactive protein (CRP) levels, and multi-vessel disease. 30866520 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease RGD Besides serum chemerin, the levels of chemerin/CMKLR1 in the metabolic organs of obesity and diabetes rats were alleviated by exercise, which were likely to be associated with the improvement of glycolipid metabolism. 30873215 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 AlteredExpression disease BEFREE To investigate the influences of exercise on the levels of chemerin and its receptor chemokine-like receptor (CMKLR1) in the peripheral metabolic organs of obesity and diabetes rats, and whether the mechanism is related to peroxisome proliferator activated receptor γ (PPARγ), a key modulator of glycolipid metabolism. 30873215 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 AlteredExpression disease BEFREE In this study, we evaluated the expression and function of chemerin and CMKLR1 in the ovaries and granulosa cells of high-fat diet-induced obese (OB) mice. 30722991 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Additional studies are required to determine if obesity influences cancer initiation or progression through increased adipose tissue production of chemerin and/or altered chemerin processing that leads to changes in chemerin signaling in the tumor microenvironment. 31561459 2019
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE While increased total serum chemerin is a consistent finding among rodent obesity models, this may not accurately reflect changes in chemerin bioactivity which is the major determinant of biological effects. 29414326 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Given the association of chemerin with obesity and related diseases, we decided to study in detail the regulation of chemerin and CMKLR1 expression in white adipose tissue (WAT). 30257454 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Furthermore, proteomic analysis of the adipose tissue secretome has recently identified several novel adipokines including vaspin, chemerin and pref-1 that are associated with obesity and insulin resistance in humans and functionally impact on insulin signalling pathways. 29760587 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE <b>Conclusions:</b> PEDF and Chemerin arose as biomarkers of obesity and metaflammation respectively, providing a link between chronic inflammation and excess of body weight in RA. 30123797 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 AlteredExpression disease BEFREE Chemerin, a chemoattractant protein, acts <i>via</i> a G-protein coupled chemokine receptor, <i>i.e.</i> Chemokine like Receptor 1/ChemR23; levels of which are elevated in pro-inflammatory states such as obesity and type 2 diabetes mellitus (T2DM). 29682177 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE This finding together with the positive association of chemerin and leptin with markers of insulin resistance, suggests that these adipokines and more especially chemerin and leptin accompanied by their adipose tissue expression could contribute to the increased insulin resistance and low grade inflammation that characterizes GDM-obese women. 29337272 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Local effects of chemerin from fat may explain this discrepancy and support chemerin's association with hypertension and obesity. 29467310 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Ovarian chemerin was upregulated by 5α-dihydrotestosterone (DHT) in lean and overweight rats; while increased serum chemerin levels were only evident in overweight rats, suggesting that the serum chemerin may be reflective of a systemic response and associated with obesity, whereas increased ovarian chemerin expression is a localized response independent of the metabolic status. 29688269 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Together, the exciting findings gathered in the last decade clearly indicate a crucial multifaceted role for chemerin in the regulation of energy balance, making it a promising candidate for urgently needed pharmacological treatment strategies for obesity. 29848608 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Chemerin, a newly identified adipokine secreted by adipose tissue, is known to be associated with obesity, metabolic syndrome, and insulin resistance. 30598628 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE In this review article, we aim to evaluate the current literature in understanding the role of Chemerin in vascular health and furthermore, its role in maintaining vascular homeostasis with respect to inflammation, obesity and associated Metabolic Syndrome (MetS) risk factors. 30016719 2018
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Overweight/obese adolescents had significantly higher mean nocturnal serum chemerin area under the curve (AUC) levels (348.2±133.3 vs. 241.7±67.7 vs. ng/mL×h, p<0.001) compared to normal-weight controls. 27941174 2017
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-<i>γ</i> Coativator-1 Genes and the Risk for Obesity. 28947843 2017
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 Biomarker disease BEFREE The purpose of this study was to quantify two molecules (ghrelin and chemerin), released in association with food intake and obesity, in periodontally healthy and diseased individuals with respect to different body mass categories. 28631313 2017
Entrez Id: 5919
Gene Symbol: RARRES2
RARRES2
0.300 AlteredExpression disease BEFREE A high level of chemerin in humans is considered as a marker of inflammation in insulin resistance and obesity as well as in type 2 diabetes mellitus. 28625137 2017