Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5733
Gene Symbol: PTGER3
PTGER3
0.300 Biomarker disease CTD_human Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders. 21966456 2011
Entrez Id: 1308
Gene Symbol: COL17A1
COL17A1
0.030 Biomarker disease BEFREE Immunoblot assay revealed that the majority of MMP patients had IgG (93 of 124, 75%) and/or IgA autoantibodies (63 of 124, 51%) to BP180 (including its soluble ectodomains, 120-kDa LAD-1 and 97-kDa LABD97 antigens). 16403100 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.030 Biomarker disease BEFREE TGF-beta1 and IFN-gamma mRNAs were identified in 9 and 11 CP cases, respectively. 12558956 2003
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.030 AlteredExpression disease LHGDN IL-4, IL-5, TGF-beta1 and IFN-gamma mRNAs detected by a new in situ amplification system in cicatricial pemphigoid. 12366695 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.030 Biomarker disease LHGDN Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis. 12061838 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.030 Biomarker disease BEFREE Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis. 12061838 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.030 Biomarker disease BEFREE TGF-beta1 and IFN-gamma mRNAs were identified in 9 and 11 CP cases, respectively. 12366695 2002
Entrez Id: 1308
Gene Symbol: COL17A1
COL17A1
0.030 Biomarker disease BEFREE Our data demonstrate a heterogeneous binding pattern of autoantibodies to BP180 NC16A in patients with CP. 11916132 2002
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.030 Biomarker disease BEFREE The frequency of HLA-DQB1*0301 was significantly increased in the MMP patients compared with the controls (96% vs. 48%; corrected P, Pc = 0.001; relative risk, RR = 28.73). 11736906 2001
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.030 Biomarker disease BEFREE Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production. 11531829 2001
Entrez Id: 3119
Gene Symbol: HLA-DQB1
HLA-DQB1
0.030 Biomarker disease BEFREE HLA-DQB1*0301 encodes a negative charge at position DQ 57 (Asp), a critical position in peptide binding to the HLA-DQ molecule groove and therefore we speculate that this molecule may play a role in the selection of BMZ peptides in CP. 9683867 1998
Entrez Id: 1308
Gene Symbol: COL17A1
COL17A1
0.030 GeneticVariation disease BEFREE Sixteen of 23 CP sera (70%) reacted with one or both of these antigenic sites of BP180. 8592065 1996
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 AlteredExpression disease BEFREE In CP IL-4 mRNA expression was present in 4 out of 14 cases analysed.IL-5 was detected in 12 CP biopsies. 12558956 2003
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.020 Biomarker disease BEFREE In CP IL-4 mRNA expression was present in 4 out of 14 cases analysed.IL-5 was detected in 12 CP biopsies. 12558956 2003
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.020 Biomarker disease BEFREE In CP, IL-4 mRNA expression was present in 4 out of the 14 cases analysed.IL-5 was detected in 12 CP biopsies. 12366695 2002
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.020 AlteredExpression disease LHGDN IL-4, IL-5, TGF-beta1 and IFN-gamma mRNAs detected by a new in situ amplification system in cicatricial pemphigoid. 12366695 2002
Entrez Id: 3567
Gene Symbol: IL5
IL5
0.020 AlteredExpression disease LHGDN IL-4, IL-5, TGF-beta1 and IFN-gamma mRNAs detected by a new in situ amplification system in cicatricial pemphigoid. 12366695 2002
Entrez Id: 3577
Gene Symbol: CXCR1
CXCR1
0.010 AlteredExpression disease BEFREE Conjunctival expression of IL8 and CXCR1 was significantly increased in oMMP patients when compared to both healthy subjects and pSS patients. 31486595 2020
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.010 Biomarker disease BEFREE Evaluation of IL8 pathway on the ocular surface: new insights in patients with ocular mucous membrane pemphigoid. 31486595 2020
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.010 Biomarker disease BEFREE Mucous Membrane Pemphigoid, Bullous Pemphigoid, and Anti-programmed Death-1/ Programmed Death-Ligand 1: A Case Report of an Elderly Woman With Mucous Membrane Pemphigoid Developing After Pembrolizumab Therapy for Metastatic Melanoma and Review of the Literature. 30320114 2018
Entrez Id: 140805
Gene Symbol: HT
HT
0.010 Biomarker disease BEFREE A case report describes a patient who presented with desquamative gingivitis and vesicular lesions, and was diagnosed with mucous membrane pemphigoid and Hashimoto's thyroiditis. 28634600 2017
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1
0.010 Biomarker disease BEFREE Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease. 28456612 2017
Entrez Id: 3898
Gene Symbol: LAD1
LAD1
0.010 Biomarker disease BEFREE Immunoblot assay revealed that the majority of MMP patients had IgG (93 of 124, 75%) and/or IgA autoantibodies (63 of 124, 51%) to BP180 (including its soluble ectodomains, 120-kDa LAD-1 and 97-kDa LABD97 antigens). 16403100 2006
Entrez Id: 871
Gene Symbol: SERPINH1
SERPINH1
0.010 Biomarker disease LHGDN Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis. 12061838 2002
Entrez Id: 871
Gene Symbol: SERPINH1
SERPINH1
0.010 Biomarker disease BEFREE Heat shock protein 47 (HSP47) is thought to play an important role in fibrogenesis, but its role in skin lesions of cicatricial pemphigoid is not yet known. 12061838 2002