Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100653365
Gene Symbol: BED
BED
0.010 GeneticVariation disease BEFREE Patients with small lung metastases (volumes < 11 cc) had better LC and OS when using SBRT doses of BED ≥100Gy<sub>10</sub>. 28143558 2017
Entrez Id: 1471
Gene Symbol: CST3
CST3
0.010 AlteredExpression disease BEFREE We hypothesized that cord blood cystatin C (CysC) levels are elevated in neonates who have life-threatening pulmonary hypoplasia and oligohydramnios due to severe renal dysfunction. 28681080 2017
Entrez Id: 11167
Gene Symbol: FSTL1
FSTL1
0.010 Biomarker disease BEFREE Fstl1-deficient mice exhibit reduced airspaces, impaired alveolar epithelial cell differentiation, and insufficient production of surfactant proteins similar to PH in human CDH. 28188034 2017
Entrez Id: 11010
Gene Symbol: GLIPR1
GLIPR1
0.010 Biomarker disease BEFREE Therefore, GLIPR1 deserves further investigation in the context of none-small lung cancer (NSCLC). 28771580 2017
Entrez Id: 286204
Gene Symbol: CRB2
CRB2
0.010 GeneticVariation disease BEFREE This report expands the phenotype of CRB2 mutations to include lung hypoplasia and uretero-pelvic renal anomalies, and confirms cardiac malformation as a feature. 26925547 2016
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.010 Biomarker disease BEFREE Potential miRNA pathways relevant to nitrofen-induced lung hypoplasia include PI3K, TGF-β, and cell cycle kinases. 26720608 2016
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.010 Biomarker disease BEFREE Potential miRNA pathways relevant to nitrofen-induced lung hypoplasia include PI3K, TGF-β, and cell cycle kinases. 26720608 2016
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
0.010 Biomarker disease BEFREE Potential miRNA pathways relevant to nitrofen-induced lung hypoplasia include PI3K, TGF-β, and cell cycle kinases. 26720608 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.010 Biomarker disease BEFREE Potential miRNA pathways relevant to nitrofen-induced lung hypoplasia include PI3K, TGF-β, and cell cycle kinases. 26720608 2016
Entrez Id: 3934
Gene Symbol: LCN2
LCN2
0.010 Biomarker disease BEFREE LCN2 may be a potentially useful biomarker for lung hypoplasia in a rat and human CDH. 27592368 2016
Entrez Id: 4920
Gene Symbol: ROR2
ROR2
0.010 Biomarker disease BEFREE Downstream therapeutic targeting of the Wnt5a-TMEM67-ROR2 axis might, therefore, reduce or prevent pulmonary hypoplasia in ciliopathies and other congenital conditions. 26035863 2015
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1
0.010 Biomarker disease BEFREE Our results suggest that oxidative damage may be play a important role in patients with N-SCLC, and that GSTM1 and GSTT1 null genotypes may predispose the cells of patients with N-SCLC to increased oxidative damage. 25472599 2014
Entrez Id: 2946
Gene Symbol: GSTM2
GSTM2
0.010 GeneticVariation disease BEFREE Our objective is to investigate the genetic polymorphisms of the glutathione S-transferase M1 and T1 genes (GSTM1 and GSTT1) and evaluate oxidative damage in patients with non-small lung cancer (N-SCLC). 25472599 2014
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.010 GeneticVariation disease BEFREE Our results suggest that oxidative damage may be play a important role in patients with N-SCLC, and that GSTM1 and GSTT1 null genotypes may predispose the cells of patients with N-SCLC to increased oxidative damage. 25472599 2014
Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
0.010 GeneticVariation disease BEFREE We report a case of recurrent oligohydramnios in a mother with an ErbB4 mutation and speculate that the effects on the placenta through decreased vascularization contributed to oligohdyramnios and subsequent pulmonary hypoplasia in the newborn. 23344421 2013
Entrez Id: 1072
Gene Symbol: CFL1
CFL1
0.010 AlteredExpression disease BEFREE Human non-small lung cancer H1299 cells harboring a tet-on gene expression system were used to induce exogenous expression of wild-type CFL-1. 23362981 2013
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.010 Biomarker disease BEFREE ASO to CD1 inhibited proliferation of non-small lung cancer cells and mesothelioma cells. 22110187 2011
Entrez Id: 170474
Gene Symbol: HFM
HFM
0.010 Biomarker disease BEFREE Hemifacial microsomia with pulmonary hypoplasia. 22750194 2010
Entrez Id: 2626
Gene Symbol: GATA4
GATA4
0.010 Biomarker disease BEFREE Prenatal retinoic acid up-regulates pulmonary gene expression of COUP-TFII, FOG2, and GATA4 in pulmonary hypoplasia. 19853750 2009
Entrez Id: 7026
Gene Symbol: NR2F2
NR2F2
0.010 Biomarker disease BEFREE Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is a transcription factor in the steroid/thyroid hormone receptor superfamily, and targeted ablation of COUP-TFII causes CDH and associated lung hypoplasia in mice. 19853750 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.010 GeneticVariation disease BEFREE Small lung volumes were prospectively associated with an increased risk for poor cognitive function and dementia in non-carriers of the APOE epsilon4 gene. 19907180 2009
Entrez Id: 4774
Gene Symbol: NFIA
NFIA
0.010 Biomarker disease BEFREE It was shown that loss of NFIA results in hydrocephalus and agenesis of the corpus callosum and that NFIB deficiency leads to neurological defects and to severe lung hypoplasia, whereas Nfic knockout mice exhibit specific tooth defects. 17353270 2007
Entrez Id: 3952
Gene Symbol: LEP
LEP
0.010 AlteredExpression disease BEFREE Fetoscopic endoluminal tracheal occlusion performed in the sheep model to correct lung hypoplasia increased leptin expression, partially restored KGF expression, and fully restored neuregulin expression. 17676984 2007
Entrez Id: 4781
Gene Symbol: NFIB
NFIB
0.010 Biomarker disease BEFREE It was shown that loss of NFIA results in hydrocephalus and agenesis of the corpus callosum and that NFIB deficiency leads to neurological defects and to severe lung hypoplasia, whereas Nfic knockout mice exhibit specific tooth defects. 17353270 2007
Entrez Id: 2693
Gene Symbol: GHSR
GHSR
0.010 Biomarker disease BEFREE Overexpression of ghrelin in hypoplastic lungs and the effect of exogenous administration of ghrelin to nitrofen-treated dams strongly suggest a role for ghrelin in mechanisms involved in attenuation of fetal lung hypoplasia, most likely through a GHSR1a-independent pathway. 16549524 2006