Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55654
Gene Symbol: TMEM127
TMEM127
0.320 SusceptibilityMutation disease ORPHANET The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. 24334765 2014
Entrez Id: 201163
Gene Symbol: FLCN
FLCN
0.900 AlteredExpression disease BEFREE A bona fide tumour suppressor activity of FLCN was confirmed by nude mouse xenograft assays of two human RCC cell lines with either diminished or re-expressed FLCN. 19843504 2010
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. 17482131 2007
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Significant decrease (P<0.05) in LimD1 and VHL expression was observed in different subtypes of RCC and in early invasive lesions. 29033184 2017
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Furthermore, the findings of homozygous inactivation of the VHL gene in a G1 tumor support the notion that the inactivation of the VHL gene is an early event in tumorigenesis of renal cell carcinoma. 8641695 1996
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE The aim of this study was to investigate the association of Von Hippel-Lindau (VHL) gene status, vascular endothelial growth factor receptor (VEGFR) or stem cell factor receptor (KIT) expression, and their relationships with characteristics and clinical outcome of advanced ccRCC. 26228213 2015
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE As the identification of novel pVHL targets might provide insights into pVHL tumour suppressor activity, we performed gene expression microarray analysis in VHL-wild-type and VHL-null renal cell carcinoma (RCC) cell lines. 15824735 2005
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. 18359287 2008
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE A C-terminal truncated VHL mutant expressed by RCC cell line A498 was detected only by the N-terminal antibody but not by the C-terminal antibody as expected. 9724095 1998
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE To develop a radiomics model with all-relevant imaging features from multiphasic computed tomography (CT) for differentiating clear cell renal cell carcinoma (ccRCC) from non-ccRCC and to investigate the possible radiogenomics link between the imaging features and a key ccRCC driver gene-the von Hippel-Lindau (VHL) gene mutation. 30523454 2019
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE TGFBI-promoted adhesion, migration and invasion of human renal cell carcinoma depends on inactivation of von Hippel-Lindau tumor suppressor. 22341602 2012
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma. 28969028 2017
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL). 27595394 2016
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Clear cell renal cell cancer (CC-RCC) is a highly chemoresistant tumor characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene. 17486080 2007
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma. 15893810 2005
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE HIF-1α, HIF-2α and CAIX were up-regulated in 88.2% (15/17), 100% (17/17) and 88.2% (15/17) of tumors respectively and their expression is independent of VHL status. hnRNP A2/B1 and osteopontin expression was variable in CCRCCs and had no association with VHL genetic status. 20978319 2010
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE We discovered that the expression of two of these factors-GRHL1 and GRHL2-are downregulated in ccRCC samples, and their expression is correlated with the expression of VHL gene. 28543713 2017
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Clear-cell renal-cell carcinoma (ccRCC) is characterized by loss of a functional Von Hippel-Lindau (VHL) protein. 29503246 2018
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Taken together, the findings of this study suggest that the protein levels of HIF2A and VEGFA in tumor tissue may serve as independent prognostic factors in ccRCC. ccRCC patients with increased intratumoral HIF2A and VEGFA protein levels, and unaltered VHL protein levels, are not likely to benefit from sunitinib treatment following nephrectomy; however, this hypothesis requires verification by large‑scale replication studies. 31268155 2019
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE A review of relevant published literature regarding VEGF, von Hippel-Lindau (VHL) gene inactivation, and VEGF overexpression in RCC was performed. 15793222 2005
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE VHL protein (pVHL) expression was evaluated by immunoblotting in the human RCC cell lines CAKI, ACHN, 786‑O, 769‑P and A498. 29845253 2018
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways. 12692265 2003
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Approximately 70% of RCCs are clear-cell type (ccRCC), and in >80% the von Hippel-Lindau (VHL) gene is mutated or silenced. 26219258 2015
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Our results provide a possible mechanistic explanation for the role of SENP1 in the initiation and development of ccRCC with normal VHL activity, and identifies SENP1 as a potential treatment target for the disease. 27741516 2016
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.800 AlteredExpression disease BEFREE Finally, immunohistochemical staining of Cyr61/CCN1 and CTGF/CCN2 in RCC tissue samples showed that increased expression of these proteins correlates with the loss of VHL protein expression. 18212329 2008