Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 AlteredExpression disease BEFREE Intracranial Inflammatory Myofibroblastic Tumor with Negative Expression of Anaplastic Lymphoma Kinase: A Case Report and Review of the Literature. 30735872 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE Inflammatory myofibroblastic tumor (IMT) is a rare benign cancer that can express a more aggressive phenotype related to the genetic mutation of the anaplastic lymphoma kinase receptor (ALK). 30900517 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE We advocate scrutinizing patients with presumptive single organ IgG4-RD for IMT and the diagnostic algorithm should include ALK and ROS1 immunohistochemistry and, in selected cases, a next-generation sequencing-based fusion assay that covers known IMT-associated gene fusions. 30451733 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE ALK is a receptor tyrosine kinase, associated with many tumor types as diverse as anaplastic large cell lymphomas, inflammatory myofibroblastic tumors, breast and renal cell carcinomas, non-small cell lung cancer, neuroblastomas, and more. 30813562 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 AlteredExpression disease BEFREE Our results indicate that ALK expression in AFH is common, particularly with the highly sensitive D5F3 and 5A4 antibodies and enhanced detection systems, and may be a potential source of diagnostic confusion with IMT. 29877921 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Crizotinib, a first-generation ALK inhibitor, has been shown to have a notable response in patients with ALK-positive IMT. 30790150 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE We used RNA-sequencing to search for alternate fusion events in an ALK-negative IMT. 30735274 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE Five CFTs were analyzed for IMT-related rearrangements in ALK, ROS1 and RET using fluorescence in situ hybridization (FISH). 31202195 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE This is the first report of a fusion partner gene of ALK in a case of laryngeal IMT. 31215130 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE It is known, however, that ALK gene rearrangements are common in inflammatory myofibroblastic tumors, similar to non-small cell lung cancer. 29925295 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE Of note, 1 tumor previously diagnosed as leiomyosarcoma was established as inflammatory myofibroblastic tumor along this study with a novel ALK-TNS1 fusion. 31121144 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE We report two emblematic cases of IMT in pediatric patients, treated with the second-generation ALK inhibitor ceritinib in the context of a clinical trial (NCT01742286). 30697903 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE One exceptional case of a RANBP2-ALK-positive epithelioid inflammatory myofibroblastic sarcoma (an aggressive variant of IMT) showed moderate cytoplasmic staining for pan-Trk. 31578734 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 AlteredExpression disease BEFREE One PD-L1, CD8-enriched leiomyosarcoma showed an ALK overexpression suggesting possible classification as inflammatory myofibroblastic tumor, but otherwise lacked morphologic features of this entity. 31009388 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE This report describes a woman aged 22 years with unresectable ALK-negative IMT. 31805529 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE Inflammatory myofibroblastic tumors are characterized by rearrangements involving the anaplastic lymphoma kinase gene locus on 2p23. 29898011 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE A molecular-targeted drug (anaplastic lymphoma kinase inhibitor) was found to be extremely effective as selective therapy for inflammatory myofibroblastic tumor with anaplastic lymphoma kinase translocation. 31615346 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 AlteredExpression disease BEFREE IHC confirmed the diagnosis by detecting the expression of ALK protein.After ALK positivity was proven, the effectiveness and safety of the crizotinib therapy was examined in 4 patients (1 alveolar rhabdomyosarcoma (RMA), 1 embryonal rhabdomyosarcoma (RME), 1 inflammatory myofibroblastic tumor (IMT), 1 NBL). 29081033 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Herein, we report the first case of IMT which harbors an ALK gene amplification rather than a rearrangement thus resulting in overexpression of the protein, arising from the femur of a 24-year-old man. 31326196 2019
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Inflammatory myofibroblastic tumor has ALK gene rearrangements and is considered a neoplasm as opposed to PCG, which is a reactive polyclonal plasma cell proliferation. 30040458 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Treatment-refractory ALK-positive inflammatory myofibroblastic tumour of the oral cavity. 29643133 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE As preliminary data are promising, a prospective study evaluating crizotinib treatment in patients with unresectable/multifocal ALK<sup>+</sup> IMT/EIMS is warranted. 29286567 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 GeneticVariation disease BEFREE All 14 IMTs were confirmed to harbor ALK genetic fusion by RNA sequencing, and ALK immunostaining in the form of granular cytoplasmic positivity with paranuclear accentuation was observed in all 14 cases. 30015720 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion with other oncogenes (NPM, EML4, TIM, etc) or gene amplification, mutation or protein overexpression. 29455642 2018
Entrez Id: 238
Gene Symbol: ALK
ALK
0.700 Biomarker disease BEFREE We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. 29669701 2018