Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression phenotype BEFREE This was associated with increased neutrophilic airway inflammation, vascular permeability, myeloperoxidase activity in the lung with upregulated expression of NADPH oxidase (NOX2)/MCP-1/TNF-α in neutrophils and IL-17A in γδ T cells/lung. 30611000 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression phenotype BEFREE In VECs, low expression of HOXA11-AS can inhibit the expression of TNF-α-induced pro-inflammatory genes and PDGF-induced vascular inflammation-related genes. 30402857 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression phenotype BEFREE In vivo studies indicated that the expression of SIRT1, SIRT6 was decreased and the expression of MCP-1, IL-6 and IL-1β was increased in carotid collar-induced vascular inflammation. 28477980 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression phenotype BEFREE FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation. 31110200 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 AlteredExpression phenotype BEFREE Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflammation. 21311042 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 AlteredExpression phenotype BEFREE In lysates of thoracic aorta from WT mice maintained on a HF diet, markers of vascular inflammation both upstream (IKKbeta activity) and downstream of the transcriptional regulator, NF-kappaB (ICAM protein and IL-6 mRNA expression), were increased and this effect was associated with cellular insulin resistance and impaired insulin stimulation of eNOS. 17478729 2007
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.080 AlteredExpression phenotype BEFREE In conclusion, TSP-4, a matricellular protein involved in regulating vascular inflammation, plays a role in establishing recurrent coronary risk in post-infarction patients with high levels of HDL-C and CRP. 22011848 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 AlteredExpression phenotype BEFREE To help elucidate the role of calcineurin in vascular inflammation, we infected cultured vascular smooth muscle cells (VSMCs) with an adenovirus construct expressing a constitutively active mutant of calcineurin, and examined its effect on the expression of monocyte chemoattractant protein-1 (MCP-1). 14739159 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.070 AlteredExpression phenotype BEFREE Inducible heme oxygenase-1 and downstream proteins biliverdin reductase and p21, a cyclin-dependent kinase, were up-regulated, potentially contributing to phenotypic heterogeneity and absence of atherosclerosis in patients with sickle cell disease despite endothelial dysfunction and vascular inflammation. 15031206 2004
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 AlteredExpression phenotype BEFREE This strategy inhibited early vascular inflammation (monocyte infiltration, increased expression of MCP-1, and inflammatory cytokines) and late neointimal hyperplasia. 12065319 2002
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.070 AlteredExpression phenotype BEFREE In vivo studies indicated that the expression of SIRT1, SIRT6 was decreased and the expression of MCP-1, IL-6 and IL-1β was increased in carotid collar-induced vascular inflammation. 28477980 2017
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.070 AlteredExpression phenotype BEFREE In conclusion, curcumin inhibits vascular inflammation in vivo and in vitro through the activation of HO-1. 30327711 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.060 AlteredExpression phenotype BEFREE In vivo studies indicated that the expression of SIRT1, SIRT6 was decreased and the expression of MCP-1, IL-6 and IL-1β was increased in carotid collar-induced vascular inflammation. 28477980 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.060 AlteredExpression phenotype BEFREE Mechanistically, the reduction of SIRT1 was shown to increase vascular cell senescence and upregulate p21 expression, as well as enhance vascular inflammation. 27650558 2016
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.050 AlteredExpression phenotype BEFREE Herein we report that the matrikine acetylated Pro-Gly-Pro (PGP) stimulates vascular inflammation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endothelin-1 both in vitro and in vivo. 28790330 2017
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
0.040 AlteredExpression phenotype BEFREE In conclusion, this study suggests that circulating VK1 has a positive effect in lowering vascular inflammation in T2D by regulating NF-κB/Nrf2 transcription factors via activating VK-dependent Gla proteins. 29227493 2018
Entrez Id: 406913
Gene Symbol: MIR126
MIR126
0.040 AlteredExpression phenotype BEFREE Reduced miR-126 expression was accompanied by increased vascular inflammation as evident from the levels of vascular adhesion molecule-1 and fibrinogen, as well as leukocyte counts. 27127202 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.040 AlteredExpression phenotype BEFREE These findings suggest that NADPH oxidase activation, mRNA stabilization, and MAPK signaling pathways play critical roles in LPS-enhanced TLR4 expression in HASMCs, which contributes to vascular inflammation and cardiovascular disorders. 17008589 2006
Entrez Id: 6283
Gene Symbol: S100A12
S100A12
0.040 AlteredExpression phenotype BEFREE This review summarizes the roles of S100 proteins (S100A8, S100A9 and S100A12) in the vascular inflammation, vascular calcification and vascular oxidative stress. 31794767 2020
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.040 AlteredExpression phenotype BEFREE In conclusion, this study suggests that circulating VK1 has a positive effect in lowering vascular inflammation in T2D by regulating NF-κB/Nrf2 transcription factors via activating VK-dependent Gla proteins. 29227493 2018
Entrez Id: 4353
Gene Symbol: MPO
MPO
0.040 AlteredExpression phenotype BEFREE The current methods paper provides a detailed protocol to determine in vivo and ex vivo MPO activity in arteries from mouse models of vascular inflammation and disease by utilizing the conversion of hydroethidine to 2-Cl-E(+). 27184954 2016
Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
0.030 AlteredExpression phenotype BEFREE Nucleotide P2Y<sub>2</sub> receptor (P2Y<sub>2</sub>R) contributes to vascular inflammation by increasing vascular cell adhesion molecule-1 expression in endothelial cells (EC), and global P2Y<sub>2</sub>R deficiency prevents fatty streak formation in apolipoprotein E null (ApoE<sup>-/-</sup>) mice. 27856454 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.030 AlteredExpression phenotype BEFREE In male mice, EC-MR deletion attenuates leukocyte-endothelial interactions, plaque inflammation, and expression of E-selectin and ICAM-1, providing a potential mechanism by which the MR promotes vascular inflammation. 31294624 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.030 AlteredExpression phenotype BEFREE We observed profound changes in mRNA levels for markers of tubular damage (Kim-1, NGAL) and regeneration (indirect marker of tubular injury, Ki-67), and tissue and vascular inflammation (IL-6, E-selectin, P-selectin, ICAM-1) in kidneys of PHZ-treated mice, associated with ultrastructural signs of tubular injury. 29545789 2018
Entrez Id: 1803
Gene Symbol: DPP4
DPP4
0.030 AlteredExpression phenotype BEFREE Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. 29677638 2018