Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
0.010 Biomarker disease BEFREE We evaluated the diagnostic accuracy and interpathologist agreement of two anti-ROS1 IHC clones, SP384 (Ventana, Tucson, Arizona) and D4D6 (Cell Signaling, Danvers, Massachusetts), in a training cohort of 51 positive ROS1 FISH LUAD cases, and then in a large validation cohort of 714 consecutive cases of LUAD from six routine molecular pathology platforms. 30999109 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.010 GeneticVariation disease BEFREE We report a patient with brain metastatic lung adenocarcinoma in whom fatal myocarditis developed after sequential use of PD-1 and PD-L1 inhibitors. 31022941 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.010 Biomarker disease BEFREE To examine the serum levels of carcinoembryonic antigen (CEA), cytokeratin-19 fragments (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate antigen (CA) 19-9, CA125, tissue polypeptide antigen (TPA), tissue polypeptide specific antigen (TPS), and lactate dehydrogenase (LDH) to predict de novo metastatic lung adenocarcinoma. 31356196 2019
Entrez Id: 3880
Gene Symbol: KRT19
KRT19
0.010 Biomarker disease BEFREE To examine the serum levels of carcinoembryonic antigen (CEA), cytokeratin-19 fragments (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate antigen (CA) 19-9, CA125, tissue polypeptide antigen (TPA), tissue polypeptide specific antigen (TPS), and lactate dehydrogenase (LDH) to predict de novo metastatic lung adenocarcinoma. 31356196 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.010 AlteredExpression disease BEFREE To examine the serum levels of carcinoembryonic antigen (CEA), cytokeratin-19 fragments (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate antigen (CA) 19-9, CA125, tissue polypeptide antigen (TPA), tissue polypeptide specific antigen (TPS), and lactate dehydrogenase (LDH) to predict de novo metastatic lung adenocarcinoma. 31356196 2019
Entrez Id: 2150
Gene Symbol: F2RL1
F2RL1
0.010 Biomarker disease BEFREE Our finding also suggests that PAR2 might serve as a therapeutic target for metastatic lung adenocarcinoma and a potential biomarker for predicting the prognosis of lung adenocarcinoma. 30321617 2019
Entrez Id: 2026
Gene Symbol: ENO2
ENO2
0.010 Biomarker disease BEFREE To examine the serum levels of carcinoembryonic antigen (CEA), cytokeratin-19 fragments (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate antigen (CA) 19-9, CA125, tissue polypeptide antigen (TPA), tissue polypeptide specific antigen (TPS), and lactate dehydrogenase (LDH) to predict de novo metastatic lung adenocarcinoma. 31356196 2019
Entrez Id: 9468
Gene Symbol: PCYT1B
PCYT1B
0.010 Biomarker disease BEFREE Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma. 31400757 2019
Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
0.010 Biomarker disease BEFREE We report a patient with brain metastatic lung adenocarcinoma in whom fatal myocarditis developed after sequential use of PD-1 and PD-L1 inhibitors. 31022941 2019
Entrez Id: 10576
Gene Symbol: CCT2
CCT2
0.010 Biomarker disease BEFREE Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma. 31400757 2019
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.010 Biomarker disease BEFREE Postoperative pathology and western blotting disclosed a prolactin-positive metastatic lung adenocarcinoma. 30137505 2019
Entrez Id: 51755
Gene Symbol: CDK12
CDK12
0.010 GeneticVariation disease BEFREE Quantitative Mass Spectrometry to Interrogate Proteomic Heterogeneity in Metastatic Lung Adenocarcinoma and Validate a Novel Somatic Mutation CDK12-G879V. 30617155 2019
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
0.010 AlteredExpression disease BEFREE The aim of the present study was to investigate the associations between ERα/ERβ expression and EGFR mutational status and response to TKI treatment in metastatic lung adenocarcinoma. 30013628 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.010 AlteredExpression disease BEFREE The aim of the present study was to investigate the associations between ERα/ERβ expression and EGFR mutational status and response to TKI treatment in metastatic lung adenocarcinoma. 30013628 2018
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.010 Biomarker disease BEFREE We investigated the predictive role of dual-time-point <sup>18</sup>F-FDG PET/CT to distinguish primary and metastatic lung adenocarcinoma in SPN. 29714664 2018
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
0.010 AlteredExpression disease BEFREE Metastatic lung adenocarcinoma in the adrenal gland had occasional (36%) expression, while metastatic clear cell renal cell carcinoma in the adrenal gland did not express GATA3. 28374498 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.010 Biomarker disease BEFREE Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinoma. 26883469 2016
Entrez Id: 4654
Gene Symbol: MYOD1
MYOD1
0.010 Biomarker disease BEFREE Expression of ERCC1, TYMS, TUBB3, non‑muscle myosin II, myoglobin and MyoD1 genes was associated with decreased survival in patients with metastatic lung adenocarcinoma. 25573098 2015
Entrez Id: 3799
Gene Symbol: KIF5B
KIF5B
0.010 Biomarker disease BEFREE Multiplex reverse transcription-polymerase chain reaction (RT-PCR) was used to detect KIF5B-RET and CCDC6-RET fusions from specimens of malignant pleural effusion (MPE) in patients with metastatic lung adenocarcinoma. 25773866 2015
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
0.010 AlteredExpression disease BEFREE Hmga2 is highly expressed in metastatic lung adenocarcinoma, in which it contributes to cancer progression and metastasis. 24305048 2014
Entrez Id: 59
Gene Symbol: ACTA2
ACTA2
0.010 Biomarker disease BEFREE Therefore, ACTA2 could be a promising prognostic biomarker and/or therapeutic target for metastatic lung adenocarcinoma. 23995859 2013
Entrez Id: 2199
Gene Symbol: FBLN2
FBLN2
0.010 AlteredExpression disease BEFREE Fibulin-2 was abundant in the extracellular matrix of human lung adenocarcinomas and was highly expressed in tumor cell lines derived from mice that develop metastatic lung adenocarcinoma from co-expression of mutant K-ras and p53. 23785517 2013
Entrez Id: 100302126
Gene Symbol: MIR1471
MIR1471
0.010 Biomarker disease BEFREE The 4 most significantly deregulated miRNAs (miR-145, miR-214, miR-9* and miR-1471) were validated in the additional 43 samples (35 primary and 8 brain metastatic lung adenocarcinoma samples) using TaqMan quantitative PCR. 24026105 2013
Entrez Id: 972
Gene Symbol: CD74
CD74
0.010 GeneticVariation disease BEFREE Resistance to crizotinib developed in a patient with metastatic lung adenocarcinoma harboring a CD74-ROS1 rearrangement who had initially shown a dramatic response to treatment. 23724914 2013
Entrez Id: 26085
Gene Symbol: KLK13
KLK13
0.010 AlteredExpression disease BEFREE Here, we provide mechanistic evidence showing that the expression of KLK13, one of the most recently identified family members, is significantly up-regulated in metastatic lung adenocarcinoma. 21596022 2011