Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes. 12213887

2002

dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE We investigated the significance of Gly1057Asp and Leu647Val insulin receptor substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186 glucose-tolerant subjects and 240 subjects with type 2 diabetes from the Lazio region (i.e. representative of central Italy), and 123 glucose-tolerant subjects from the Sicily region (i.e. representative of south Italy). 12519871

2003

dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE The effect of the Gly1057Asp mutation on type 2 diabetes and obesity was tested in a large cohort of Pima Indians (n = 998). 12765968

2003

dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study. 15127203

2004

dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE These results strongly argue against a major role of the Gly1057Asp IRS-2 polymorphism in the pathogenesis of type 2 diabetes in Djerbian subjects. 19332049

2009

dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE This meta-analysis suggested that D allele of G1057D polymorphism have a significant effect on reduced risk of T2DM, and obesity is a modifier of this association. 25959789

2015

dbSNP: rs1181860747
rs1181860747
0.070 GeneticVariation BEFREE We aimed to investigate the relationship of type 2 diabetes with a Gly972Arg (G972R) variant of the <i>IRS-1</i> gene and Gly1057Asp (G1057D) polymorphism of <i>IRS-2</i> gene in the population of Punjab, Pakistan. 31404179

2019