Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6795970
rs6795970
0.020 GeneticVariation BEFREE We also find that rs6795970 is associated with a higher risk of heart block (P < 0.05) and a lower risk of ventricular fibrillation (P = 0.01). 20062061

2010

dbSNP: rs6795970
rs6795970
0.020 GeneticVariation BEFREE In addition, the A allele remained significant after adjusting for other covariates in a multivariate model (odds ratio = 6.30 [95% confidence interval: 2.24 to 19.09], P = 0.0005).The rs6795970 in the SCN10A gene, which is reported to carry a high risk of heart block, might be associated with cardiac conduction abnormalities in HCM patients. 26104176

2015

dbSNP: rs1553259662
rs1553259662
MPZ
0.010 GeneticVariation BEFREE This case highlights that patchy demyelinating neuropathy with conduction block may occur in p.Ile112Thr MPZ mutations. 21256749

2011

dbSNP: rs374528680
rs374528680
0.010 GeneticVariation BEFREE Consequentially, the vulnerability to unidirectional conduction block in response to a premature stimulus increased at tissue level in the G1911R mutation. 27502440

2016

dbSNP: rs572010627
rs572010627
MPZ
0.010 GeneticVariation BEFREE The S140T mutation in myelin P0 can be associated with conduction block and Charcot-Marie-Tooth should be part of the differential diagnosis of that phenomenon. 12207932

2002

dbSNP: rs60682848
rs60682848
0.010 GeneticVariation BEFREE To recapitulate progressive human dilated cardiomyopathy (DCM) and heart block in the Lmna R225X mutant mice model and investigate the molecular basis of LMNA mutation induced cardiac conduction disorders (CD); To investigate the potential interventional impact of exercise endurance. 31668660

2020

dbSNP: rs62636495
rs62636495
DES
0.010 GeneticVariation BEFREE Characterization of a novel S13F desmin mutation associated with desmin myopathy and heart block in a Chinese family. 18061454

2008

dbSNP: rs587782958
rs587782958
T 0.700 CausalMutation CLINVAR