Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE These findings indicate that rs12425791 G>A polymorphism may be a low-penetrance susceptibility marker of stroke in Asian populations and further studies are warranted to verify this association. 26312640

2016

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE A recent genome-wide association study (GWAS) identified two common polymorphisms (rs12425791 and rs11833579) on chromosome 12p13 that confer risk to stroke, particularly for large artery atherosclerotic (LAA) stroke. 26687183

2016

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE These results suggested that the rs12425791 and rs11833579 polymorphisms on Chromosome 12p13 may be associated with the risk of LAA stroke and might be used as candidate biomarkers for LAA stroke susceptibility. 26145198

2015

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE rs12425791 and rs11833579 were not associated with age of stroke onset (P = 0.786 and 0.340, respectively). 24995625

2014

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan. 22212150

2012

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE In 2009, a GWAS has confirmed that rs11833579 and rs12425791 near the NINJ2 gene could increase the stroke and ischemic stroke (IS) risk. 22795341

2012

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE Recent genome-wide association studies (GWAS) have identified two key SNPs (rs11833579 and rs12425791) on chromosome 12p13 that were significantly associated with stroke in Caucasians. 22938733

2012

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE Recent genome-wide association (GWA) studies have identified two intergenic single nucleotide polymorphisms (SNPs) (rs11833579 and rs12425791) on chromosome 12p13 and within 11 kb of the NINJ2 gene that were significantly associated with stroke in Caucasians. 21376321

2011

dbSNP: rs12425791
rs12425791
0.890 GeneticVariation BEFREE Our data suggest that rs12425791 on chromosome 12p13 is a genetic marker for atherothrombotic stroke in multiethnic population. 20448654

2010

dbSNP: rs12425791
rs12425791
A 0.890 GeneticVariation GWASDB Genomewide association studies of stroke. 19369658

2009

dbSNP: rs12425791
rs12425791
A 0.890 GeneticVariation GWASCAT Genomewide association studies of stroke. 19369658

2009

dbSNP: rs2107595
rs2107595
0.850 GeneticVariation BEFREE In HDAC9 SNP rs2107595 risk allele-positive LVAS patients, there were 155 genes differentially expressed compared to risk allele-negative patients (fold change > ;1.2;, p < 0.05). 29651704

2019

dbSNP: rs2107595
rs2107595
0.850 GeneticVariation BEFREE Results- Targeted resequencing of the <i>HDAC9</i> locus in patients with atherosclerotic stroke and controls supported candidacy of rs2107595 as the causative single nucleotide polymorphism. 31500558

2019

dbSNP: rs2107595
rs2107595
0.850 GeneticVariation GWASCAT Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 29531354

2018

dbSNP: rs2107595
rs2107595
0.850 GeneticVariation BEFREE Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13, P-value = .013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26, P -value = .026) and rs2107595 (OR = 1.70; CI: 1.12-2.60, P-value = .014) and rs28688791 (OR = 1.52; CI: 1.03-2.26, P-value = .036) in HDAC9 gene were associated with SVD stroke at 0.05 significance level. 28975602

2018

dbSNP: rs2107595
rs2107595
0.850 GeneticVariation BEFREE Our results revealed statistically significant associations of the rs2107595 (T/C) polymorphism with an increased risk of stroke in the allele, codominant and dominant models. 28145521

2017

dbSNP: rs2107595
rs2107595
0.850 GeneticVariation BEFREE We further performed detailed plaque phenotyping and genotyping of rs2107595, the lead single-nucleotide polymorphism for large-vessel stroke, in carotid endarterectomy samples of 1858 subjects from the Athero-Express study. 25388417

2015

dbSNP: rs2107595
rs2107595
A 0.850 GeneticVariation GWASDB Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. 23041239

2012

dbSNP: rs2107595
rs2107595
A 0.850 GeneticVariation GWASCAT Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. 23041239

2012

dbSNP: rs11984041
rs11984041
0.830 GeneticVariation BEFREE The variant rs556621 but not rs11984041 may increase susceptibility of LAA stroke in the Xinjiang Uyghur population. 25307434

2015

dbSNP: rs11984041
rs11984041
0.830 GeneticVariation BEFREE A recent Genome-Wide Association study (GWAS) identified rs11984041 on HDAC9 gene to be significantly associated with stroke in a Caucasian population. 23828597

2013

dbSNP: rs11984041
rs11984041
A 0.830 GeneticVariation GWASCAT We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). 22306652

2012

dbSNP: rs11984041
rs11984041
A 0.830 GeneticVariation GWASDB We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). 22306652

2012

dbSNP: rs11984041
rs11984041
0.830 GeneticVariation BEFREE We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). 22306652

2012

dbSNP: rs556621
rs556621
0.820 GeneticVariation BEFREE Smoking status, sex did not significantly influence the relationship between genotypes of rs556621 and risk of LAA stroke (P <sub>interaction</sub> = 0.140, P <sub>interaction</sub> = 0.076). 27567922

2017