Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer. 31416884

2019

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). 31839644

2019

dbSNP: rs2294008
rs2294008
PSCA ; JRK
T 0.800 GeneticVariation GWASCAT Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. 30281874

2018

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>; odds ratio = 3.88, TT + TC vs CC genotype), but not with <i>H. pylori</i> infection <i>per se</i> nor with the progression from active gastritis to gastric cancer. 29423095

2018

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation BEFREE Our study confirms the protective effect of MUC1 rs4072037 polymorphism on the risk of GC under the dominant model. 28489708

2018

dbSNP: rs2294008
rs2294008
PSCA ; JRK
T 0.800 GeneticVariation GWASCAT Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. 26701879

2017

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC. 28220687

2017

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942

2017

dbSNP: rs4072037
rs4072037
T 0.800 GeneticVariation GWASCAT Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. 26701879

2017

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation BEFREE Our data suggested that rs4072037 polymorphism was associated with a decreased risk of GC. 28561882

2017

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. 26848528

2016

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215

2016

dbSNP: rs4072037
rs4072037
A 0.800 GeneticVariation GWASCAT We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers. 26129866

2016

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation BEFREE Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. 26910281

2016

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation BEFREE Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. 26910281

2016

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation BEFREE Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer. 27127881

2016

dbSNP: rs2294008
rs2294008
PSCA ; JRK
T 0.800 GeneticVariation GWASCAT Loss-of-function variants in ATM confer risk of gastric cancer. 26098866

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE The PSCA rs2294008 C>T polymorphism may be acting through induction of gastric mucosal atrophy, finally leading to development of gastric ulcer and gastric cancer in PSCA rs2294008 T allele carriers, but not duodenal ulcer. 25582162

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively. 25658482

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians. 25721731

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE Two recent genome-wide association studies in Asians have reported the association between the PSCA (prostate stem cell antigen) rs2294008C>T gene polymorphism and two Helicobacter pylori infection-related diseases such as gastric cancer (GC) and duodenal ulcer (DU). 25721731

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE Previous genomewide association studies identified prostate stem cell antigen (PSCA) as a gastric cancer (GC) susceptibility gene and showed an association between GC and the T allele of the single nucleotide polymorphism rs2294008 (C/T) in this gene. 25727947

2015

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation GWASCAT Loss-of-function variants in ATM confer risk of gastric cancer. 26098866

2015

dbSNP: rs4072037
rs4072037
0.800 GeneticVariation BEFREE Several genetic variants including PSCA rs2294008 C>T and rs2976392 G>A, MUC1 rs4072037 T>C, and PLCE1 rs2274223 A>G have shown significant association with stomach cancer risk in the previous genome-wide association studies (GWASs). 25658482

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.800 GeneticVariation BEFREE In addition, our data indicate that rs2294008 of PSCA is involved in GC susceptibility and confer its effect primarily in noncardia tumors (OR = 1.30, 95% CI 1.12-1.53, P < 10(-4)). 24146278

2014