|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
|
15805248 |
2005 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
|
22162589 |
2012 |
|
rs121913279
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We found that activation of the latent Pik3ca(H1047R) allele resulted in breast tumors with multiple histological types.
|
22370636 |
2013 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
The PIK3CA gene is mutated with high frequency in human breast cancers.
|
15254419 |
2004 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
The PIK3CA gene is mutated with high frequency in human breast cancers.
|
15254419 |
2004 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs121913279
|
|
|
0.740 |
GeneticVariation |
BEFREE |
In addition, the combined treatment of DSF and LY294002 significantly inhibited the growth of the breast tumor xenograft in nude mice induced by MDA-MB-231 cells expressing mutant PIK3CA-H1047R and PIK3CA-E545K, whereas neither DSF nor LY294002 alone could significantly retard tumor growth.
|
20424113 |
2010 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
|
21558396 |
2011 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
|
18725974 |
2008 |
|
rs121913279
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Our results suggest that the PIK3CA H1047R oncogene targets a multipotent progenitor cell and, furthermore, show that this model recapitulates features of human breast tumors with PIK3CA H1047R.
|
21482677 |
2011 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
|
18676830 |
2008 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
|
18676830 |
2008 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
|
15805248 |
2005 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.
|
22162582 |
2012 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
|
20453058 |
2010 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
|
15647370 |
2005 |
|
rs121913279
|
|
|
0.740 |
GeneticVariation |
BEFREE |
All mutations were mutually exclusive, apart from one basal-like breast tumour which harboured mutations in both MET (p.T992I) and PIK3CA (p.H1047R).
|
24318467 |
2014 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
|
22162589 |
2012 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
|
20453058 |
2010 |
|
rs121913279
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.
|
22162582 |
2012 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
|
15647370 |
2005 |
|
rs121913279
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
|
18725974 |
2008 |