Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
---|---|---|---|---|---|---|---|---|---|---|
|
A | 0.700 | CausalMutation | CLINVAR | Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. | 22162589 | 2012 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials. | 22162582 | 2012 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. | 20453058 | 2010 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. | 18725974 | 2008 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. | 18676830 | 2008 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. | 15647370 | 2005 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. | 15805248 | 2005 |
|||
|
A | 0.700 | CausalMutation | CLINVAR | The PIK3CA gene is mutated with high frequency in human breast cancers. | 15254419 | 2004 |