CP, ceruloplasmin, 1356

N. diseases: 283; N. variants: 64
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Screening of genes involved in brain iron metabolism showed a significant association of some sequence variations of the ceruloplasmin gene with PD. 16755382 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Moreover, variations in the ceruloplasmin gene were found to be associated with PD or SN hyperechogenicity. 16464747 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE High-density comparative genomic hybridization microarrays were also used to detect large-scale copy-number variations in CP and an additional 47 genes involved in PD and/or copper/iron metabolism. 25758665 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Second, Chelex 100 treatment revealed that pPD ceruloplasmin compared with ceruloplasmin of healthy individuals displayed smaller content of labile copper atoms. 29203265 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands. 31733982 2020
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Immunohistochemistry of PD midbrains was performed to examine the presence of Cp in Lewy bodies. 15557511 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease CTD_human High-density comparative genomic hybridization microarrays were also used to detect large-scale copy-number variations in CP and an additional 47 genes involved in PD and/or copper/iron metabolism. 25758665 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Ceruloplasmin in Parkinson's disease and the nonmotor symptoms. 29733522 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Previous studies showed that CP deficiency contributes to Parkinson's disease by increasing iron accumulation and oxidative stress in the substantia nigra. 28874056 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Serum Ceruloplasmin and Striatal Dopamine Transporter Density in Parkinson Disease: Comparison With 123I-FP-CIT SPECT. 28632695 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease LHGDN Immunohistochemistry of PD midbrains was performed to examine the presence of Cp in Lewy bodies. 15557511 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease CTD_human Mode of onset and duration of PD showed no relationship to ceruloplasmin. 19159062 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease LHGDN A significantly decreased ferroxidase activity was found in PD, HD and AD, agreeing with findings of iron deposition in these entities, while free copper was found to be increased in CSF and appeared to be a good biomarker of PD. 18307039 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE In 1987, Miyajima et al. first characterized an autosomal recessive, adult-onset neurodegenerative disorder resembling Parkinson's disease associated with near-absent circulating serum ceruloplasmin levels. 15105274 2004
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE These findings suggest that nigral iron deposition, correlating with decreased serum ceruloplasmin levels, is a risk factor in Parkinson's disease across multiple motor phenotypic expressions. 22288465 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE MiR-133b expression was correlated with the ceruloplasmin level in patients with PD, whereas no correlation was found between miR-133b and disease severity or motor phenotype. 25218846 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE We have previously demonstrated that reduced serum ceruloplasmin level exacerbates nigral iron deposition in Parkinson's disease, although the underlying cause of the low serum ceruloplasmin level in Parkinson's disease remains unknown. 30243884 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease LHGDN Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD. 16150804 2005
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 AlteredExpression disease BEFREE Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD. 16150804 2005