FGF4, fibroblast growth factor 4, 2249

N. diseases: 86; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 Biomarker phenotype BEFREE HST-1 and INT-2 genes which is a member of fibroblast growth factor gene family, are amplified in approximately 50% of primary tumors and all the metastatic tumors of esophageal carcinomas. 2098274 1990
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 Biomarker phenotype BEFREE Oct-3/4 can up-regulate fibroblast growth factor-4 and matrix metalloproteinase-2 (MMP-2), MMP-9, and MMP-13 production, which may contribute to tumor metastasis. 18676852 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 Biomarker phenotype BEFREE Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. 8481921 1993
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 Biomarker phenotype BEFREE The hst-1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. 3136110 1988
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 Biomarker phenotype BEFREE The fibroblast growth factor 4-transfected cells could support growth and metastasis of the beta-galactosidase-expressing parental cell line when both lines were coinjected into the same site in untreated or tamoxifen-treated, ovariectomized mice. 8481920 1993
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 Biomarker phenotype BEFREE These results suggest that int-2/hst-1 coamplification is a new biological indicator of prognosis and distant organ metastasis in patients with esophageal squamous cell carcinoma. 1997190 1991
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.070 AlteredExpression phenotype BEFREE To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed. 8685603 1996