METAP1, methionyl aminopeptidase 1, 23173

N. diseases: 6; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
0.010 Biomarker disease BEFREE The MetAPs contribute to the cotranslational control of proteins as they determine their half life (N-terminal end rule) and facilitate further modifications such as acetylation and others.Mtb (and <i>M. bovis</i>) possess two MetAP isoforms, MetAP1a and MetAP1c, encoded by the <i>mapA</i> and <i>mapB</i> genes, respectively. 31035386 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.010 Biomarker disease BEFREE Ficolin-1, ficolin-3 and MAP-1 were not associated with MI. 28216633 2017
CUI: C0242723
Disease: Parasitemia
0.010 AlteredExpression disease BEFREE Finally, rBmMetAP1 was able to provide considerable protection to mice against a B. microti challenge infection based on a reduction in peak parasitemia levels and earlier clearance of the parasite as compared with control mice. 27306898 2016
CUI: C2930674
Disease: Human Babesiosis
Human Babesiosis
0.010 Biomarker disease BEFREE Taken together, these results suggest that rBmMetAP1 confers significant protection against experimental B. microti infection and might be considered a potential vaccine target against human babesiosis. 27306898 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.010 Biomarker phenotype BEFREE Anti-MAP-1 (CSP-based) antibodies blocked the invasion of HepG2 liver cells by P. falciparum sporozoites (highest, 95.16% in HLA-A2 C57BL/6; lowest, 11.21% in BALB/c). 20823210 2010
CUI: C0027651
Disease: Neoplasms
0.010 Biomarker group BEFREE Our findings identify RASSF1A and MAP-1 as important components between death receptors and the apoptotic machinery and reveal a potential link between tumor suppression and death receptor signaling. 15949439 2005