G6PD, glucose-6-phosphate dehydrogenase, 2539

N. diseases: 410; N. variants: 66
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE A precise and reliable screening assay for glucose 6-phosphate dehydrogenase (G6PD) deficiency would greatly help avoiding unwanted outcomes due to bilirubin neurotoxicity in neonatal jaundice and antimalarial-induced haemolytic anaemia in malaria patients. 30383322 2019
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE However, this drug induces haemolytic anaemia among glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. 30819192 2019
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Here, we review aspects of TQ, including how to avoid hemolytic anemia in G6PD deficient patients. 31596137 2019
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells that cause hemolytic anemia. 30921210 2019
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Treatment with the antimalarial primaquine can result in hemolytic anemia in G6PD-deficient patients. 29141760 2018
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 GeneticVariation disease BEFREE Glucose-6-phosphate dehydrogenase (G6PD) deficiency, one of the most common human genetic enzymopathies, is caused by over 160 different point mutations and contributes to the severity of many acute and chronic diseases associated with oxidative stress, including hemolytic anemia and bilirubin-induced neurological damage particularly in newborns. 30279493 2018
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose-6-phosphate dehydrogenase (G6PD) deficient donor RBC may exhibit increased hemolysis, but it is unknown if transfusion of these units results in less effective transfusion outcomes in SCD. 29377292 2018
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE We present a rare case of rasburicase-induced methemoglobinemia and hemolytic anemia in the setting of presumed glucose-6-phosphate dehydrogenase (G6PD) deficiency. 30324040 2018
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells in human subjects, causing hemolytic anemia linked to impaired nicotinamide adenine dinucleotide phosphate (NADPH) production and imbalanced redox homeostasis in erythrocytes. 27458052 2017
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 AlteredExpression disease BEFREE His red blood cell levels were indicating Class II G6PD activity by the World Health Organization (WHO) classification, but had no history of hemolytic anemia. 28538406 2017
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Infected individuals are treated with primaquine, which can induce haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals and may lead to severe and fatal complications. 28619120 2017
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 GeneticVariation disease BEFREE One limitation of primaquine is that, at certain doses, primaquine can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd). 24891465 2014
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose 6-phosphate dehydrogenase (G6PD) deficiency, known as favism, is classically manifested by hemolytic anemia in human. 23640458 2013
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE The spatial extent of Plasmodium vivax malaria overlaps widely with that of G6PD deficiency; unfortunately the only drug licensed for the radical cure and relapse prevention of P. vivax, primaquine, can trigger severe haemolytic anaemia in G6PD deficient individuals. 23384623 2013
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. 22993389 2012
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Hemolytic anemia was also found in G6PD-deficient mice at this dosage of naphthalene. 21839656 2011
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE While many drugs are responsible for haemolytic anaemia in G6PD-deficient patients, acetaminophen's imputability is still under debate, although an overdose of this drug can provoke acute haemolytic events. 21441392 2011
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose-6-phosphate dehydrogenase deficiency poses a significant impediment to primaquine use for the elimination of liver stage infection with Plasmodium vivax and for gametocyte clearance, because of the risk of life-threatening haemolytic anaemia that can occur in G6PD deficient patients. 20684792 2010
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose-6-phosphate dehydrogenase (G6PD) deficiency--the most common known enzymopathy--is associated with neonatal jaundice and hemolytic anemia usually after exposure to certain infections, foods, or medications. 20007901 2009
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 GeneticVariation disease BEFREE Some G6PD variants cause chronic haemolysis, leading to congenital non-spherocytic haemolytic anaemia. 18177777 2008
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 GeneticVariation disease LHGDN Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of hemolytic anemia worldwide. 18677765 2008
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an important cause of hemolytic anemia worldwide. 18677765 2008
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE No death from haemolytic anaemia occurred in the G6PD- subcohort. 17182638 2007
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 Biomarker disease BEFREE We performed DNA analysis on 68 G6PD deficient children, 52 school boys and 16 children with the history of favism and hemolytic anemia using a combination of PCR-RFLP technique, single strand conformation polymorphism (SSCP) analysis and DNA sequencing. 16938474 2006
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.600 GeneticVariation disease LHGDN A novel missense mutation in glucose-6-phosphate dehydrogenase gene causing chronic nonspherocytic hemolytic anemia in an Indian family. 16944148 2006