Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.160 Biomarker disease BEFREE Our data demonstrated the essential role of APPL1 in regulating brown adipocytes thermogenesis via interaction with HDAC3, which may have potential therapeutic implications for treatment of obesity. 31390528 2019
CUI: C0028754
Disease: Obesity
Obesity
0.160 AlteredExpression disease BEFREE The expression levels of APPL1sv in liver tissues were enhanced in a mouse model of obesity and diabetic dyslipidemia (<i>i.e.</i> db/db mice) and reduced in calorie-restricted mice compared with <i>ad libitum</i>-fed mice. 29483192 2018
CUI: C0028754
Disease: Obesity
Obesity
0.160 Biomarker disease BEFREE A deep understanding of APPLs and their related signaling pathways may potentially lead to therapeutic and interventional treatments for obesity, diabetes, cancer and neurodegenerative diseases. 28108259 2017
CUI: C0028754
Disease: Obesity
Obesity
0.160 GeneticVariation disease BEFREE Genes encoding adiponectin and adiponectin receptors contribute to insulin resistance and the risk of obesity, and genetic variants of APPL1 are associated with body fat distribution. 22462604 2012
CUI: C0028754
Disease: Obesity
Obesity
0.160 AlteredExpression disease BEFREE Peak area analysis by MS validated western blot results, showing APPL1 levels to be significantly increased in type 2 diabetic and obese as compared with lean participants. 21562756 2011
CUI: C0028754
Disease: Obesity
Obesity
0.160 AlteredExpression disease BEFREE Transgenic expression of APPL1 prevented age- and obesity-induced impairment in insulin-induced vasodilation and reversed obesity-induced augmentation in insulin-evoked ET-1-dependent vasoconstriction. 21926268 2011
CUI: C0028754
Disease: Obesity
Obesity
0.160 Biomarker disease HPO