ABO, ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase, 28
N. diseases: 443; N. variants: 160
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
|
|
0.100 | Biomarker | disease | BEFREE | The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. | 28279347 | 2017 |
|
|
0.100 | Biomarker | disease | BEFREE | Effect of Helicobacter pylori Eradication and ABO Genotype on Gastric Cancer Development. | 27191536 | 2016 |
|
|
0.100 | Biomarker | disease | BEFREE | Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. | 26764597 | 2016 |
|
|
0.100 | Biomarker | disease | BEFREE | BabA is a Helicobacter pylori cell surface adhesin, which binds to the ABO/Le(b) histo-blood group antigens (Le(b)) and serves as a virulence factor. | 27318698 | 2016 |
|
|
0.100 | GeneticVariation | disease | BEFREE | Other identified associations are human immunodeficiency virus infection, ABO blood group polymorphisms, hepatitis B virus, and Helicobacter pylori. | 25726048 | 2015 |
|
|
0.100 | GeneticVariation | disease | BEFREE | ABO blood serotype A is known to be associated with risk of gastric cancer (GC), but little is known how ABO alleles and the fucosyltransferase (FUT) enzymes and genes which are involved in Lewis antigen formation [and in Helicobacter pylori (H. pylori) binding and pathogenicity] may be related to GC risk in a European population. | 24947433 | 2015 |
|
|
0.100 | GeneticVariation | disease | BEFREE | We showed that SNPs in the ABO gene, predictive of ABO blood groups, are associated with risk of advanced precancerous gastric lesions in individuals infected with Hp, but the assessment of the risk is strictly dependent on cagA status. | 23319424 | 2013 |
|
|
0.100 | Biomarker | disease | BEFREE | For instance, ABO status affects the infectivity of certain strains of Helicobacter pylori and Noroviruses as well as the sequestration and rosetting of red blood cells infected with Plasmodium falciparum. | 21945157 | 2012 |
|
|
0.100 | GeneticVariation | disease | BEFREE | Although several studies have investigated the association between ABO blood type and risk of gastric cancer (GC), atrophic gastritis (AG), and Helicobacter pylori (HP) infection, no study has investigated these associations by using ABO genotype. | 21680535 | 2011 |
|
|
0.100 | Biomarker | disease | BEFREE | The Helicobacter pylori babA gene encodes an outer membrane protein that mediates binding to fucosylated ABH antigens of the ABO blood group. | 20123715 | 2010 |
|
|
0.100 | Biomarker | disease | BEFREE | Lewis (Le)-associated antigens are carbohydrates that are related biochemically to the ABO blood groups, and may have a role in Helicobacter pylori adherence. | 16456898 | 2006 |