SMAD1, SMAD family member 1, 4086

N. diseases: 138; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE We selected an appropriate subset of variants for the investigation of common genetic risk factors and assessed SMAD1 to SMAD5 genes for association with diabetic nephropathy. 19247629 2009
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE However, functional interaction between Smad1 and Smad3 signaling in DN is unclear. 30002389 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE However, the regulatory mechanism of Smad1 in DN is still unclear. 20803090 2010
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker. 21360446 2011
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE The level of urinary IgG4 also significantly correlated with surface density of peripheral glomerular basement membrane (Sv PGBM/Glom), whereas Smad1 was associated with the degree of mesangial expansion-both classic pathological findings in DN. 29490904 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE Collagen IV (Col IV) is a major component of expanded glomerular extracellular matrix in diabetic nephropathy and Smad1 is a key molecule regulating Col IV expression in mesangial cells (MCs). 28298362 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 AlteredExpression disease BEFREE These results suggest that the modulation of Smad1 expression is responsible for the initiation and progression of diabetic nephropathy and that blocking Smad1 signaling may be beneficial in preventing diabetic nephropathy and other various diabetic complications. 14732718 2004