SMAD1, SMAD family member 1, 4086

N. diseases: 138; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.040 AlteredExpression disease BEFREE In analysis of correlation with tumor stage, both protein and mRNA expression of TGFβ1, Smad1, Smad2 and Smad4 in patients with stage III HCC were significantly lower than those with stage IV HCC (P < 0.001), while the protein and mRNA expression of Smad3 in patients with IV stage HCC was significantly higher in comparison to those with stage IV HCC (P < 0.001). 29799303 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.040 AlteredExpression disease BEFREE Decreased BMP-7 and p-Smad1/5/8 expression, and increased levels of gremlin in hepatocellular carcinoma. 30008908 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.040 Biomarker disease BEFREE Twist1-related miR-26b-5p suppresses epithelial-mesenchymal transition, migration and invasion by targeting SMAD1 in hepatocellular carcinoma. 27027434 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.040 PosttranslationalModification disease BEFREE Activin B also induces Smad1/5/8 phosphorylation in human hepatoma-derived cells and, synergistically with IL-6 and STAT-3 signaling, up-regulates hepcidin expression markedly, an observation confirmed in mouse primary hepatocytes. 22611157 2012