RNF138, ring finger protein 138, 51444

N. diseases: 15; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.030 Biomarker disease BEFREE In the current study, experiments were performed to explore the potential roles and mechanisms of RNF138 in glioblastoma in vitro and in vivo. 30272353 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.030 Biomarker disease BEFREE This study aims to clarify the role of RNF138 in GBM cells and demonstrate that rpS3 may be a promising substrate of RNF138 for the induction of GBM radioresistance, indicating RNF138 as a potential target for GBM therapy. 29371697 2018
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.030 Biomarker disease BEFREE In the current study, experiments were performed to explore the potential roles and mechanisms of RNF138 in glioblastoma in vitro and in vivo. 30272353 2018
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.030 Biomarker disease BEFREE This study aims to clarify the role of RNF138 in GBM cells and demonstrate that rpS3 may be a promising substrate of RNF138 for the induction of GBM radioresistance, indicating RNF138 as a potential target for GBM therapy. 29371697 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.030 AlteredExpression disease BEFREE By RNA interference (RNAi) with the lentivirus vector system, the expression of RNF138 was inhibited in the human astrocytomas-glioblastoma multiforme cell line U251. 22155992 2012
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.030 AlteredExpression disease BEFREE By RNA interference (RNAi) with the lentivirus vector system, the expression of RNF138 was inhibited in the human astrocytomas-glioblastoma multiforme cell line U251. 22155992 2012
CUI: C0017638
Disease: Glioma
Glioma
0.020 Biomarker disease BEFREE However, the association between RNF138 and human glioma progression remains poorly understood. 30272353 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.020 Biomarker disease BEFREE RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis. 29371697 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.020 Biomarker disease BEFREE In the current study, experiments were performed to explore the potential roles and mechanisms of RNF138 in glioblastoma in vitro and in vivo. 30272353 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.020 Biomarker disease BEFREE RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis. 29371697 2018
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.020 Biomarker disease BEFREE In the current study, experiments were performed to explore the potential roles and mechanisms of RNF138 in glioblastoma in vitro and in vivo. 30272353 2018
CUI: C0017638
Disease: Glioma
Glioma
0.020 AlteredExpression disease BEFREE The RNF138 mRNA is expressed in the five glioma cell lines, and its expression level is significantly higher in glioma tissue than in noncancerous brain tissue. 22155992 2012
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.010 Biomarker disease BEFREE Collectively, these data suggest that RNF138 modulates the cisplatin resistance in the GC cells, thus serving as a potential drug target to challenge chemotherapy failure. 30260263 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.010 Biomarker group BEFREE In vivo findings revealed that the growth of U87 cell‑transplanted tumors in nude mice was inhibited in tumors with RNF138 knockdown. 30272353 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.010 Biomarker disease BEFREE Collectively, these data suggest that RNF138 modulates the cisplatin resistance in the GC cells, thus serving as a potential drug target to challenge chemotherapy failure. 30260263 2018
CUI: C0004134
Disease: Ataxia
Ataxia
0.010 AlteredExpression phenotype BEFREE We propose that RNF138 plays a critical role in the homeostatic regulation of Ca<sub>V</sub>2.1 protein level and functional expression and that RNF138 serves as the primary E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human Ca<sub>V</sub>2.1 subunits.<b>SIGNIFICANCE STATEMENT</b> Loss-of-function mutations in the human Ca<sub>V</sub>2.1 subunit are linked to episodic ataxia type 2 (EA2), a dominantly inherited disease characterized by paroxysmal attacks of ataxia and nystagmus. 28167673 2017
CUI: C0007758
Disease: Cerebellar Ataxia
Cerebellar Ataxia
0.010 AlteredExpression phenotype BEFREE We propose that RNF138 plays a critical role in the homeostatic regulation of Ca<sub>V</sub>2.1 protein level and functional expression and that RNF138 serves as the primary E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human Ca<sub>V</sub>2.1 subunits.<b>SIGNIFICANCE STATEMENT</b> Loss-of-function mutations in the human Ca<sub>V</sub>2.1 subunit are linked to episodic ataxia type 2 (EA2), a dominantly inherited disease characterized by paroxysmal attacks of ataxia and nystagmus. 28167673 2017
CUI: C0028738
Disease: Nystagmus
Nystagmus
0.010 AlteredExpression disease BEFREE We propose that RNF138 plays a critical role in the homeostatic regulation of Ca<sub>V</sub>2.1 protein level and functional expression and that RNF138 serves as the primary E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human Ca<sub>V</sub>2.1 subunits.<b>SIGNIFICANCE STATEMENT</b> Loss-of-function mutations in the human Ca<sub>V</sub>2.1 subunit are linked to episodic ataxia type 2 (EA2), a dominantly inherited disease characterized by paroxysmal attacks of ataxia and nystagmus. 28167673 2017
CUI: C1720416
Disease: Episodic ataxia type 2 (disorder)
Episodic ataxia type 2 (disorder)
0.010 AlteredExpression disease BEFREE Disrupting endogenous RNF138 function also effectively rescues the defective protein expression of EA2 mutants, as well as fully reversing EA2 mutant-induced excessive proteasomal degradation of Ca<sub>V</sub>2.1 WT subunits. 28167673 2017
CUI: C0004114
Disease: Astrocytoma
Astrocytoma
0.010 AlteredExpression disease BEFREE By RNA interference (RNAi) with the lentivirus vector system, the expression of RNF138 was inhibited in the human astrocytomas-glioblastoma multiforme cell line U251. 22155992 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker phenotype BEFREE Whether the RING finger protein, RNF138, a newly discovered protein, plays a role in glioma oncogenesis is unknown. 22155992 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.010 Biomarker disease BEFREE However, when Wilcoxon rank sum test corrected with Q values were performed, six known genes were significantly expressed differently in the inflamed CD smokers as compared to the inflamed CD never-smokers: ring finger protein 138 (RNF138), metalothionein 2A (MT2A) and six transmembrane epithelial antigen of the prostate 3 (STEAP3), SA hypertension-associated homolog, PGM2L1 and KCNJ2. 19603079 2009